丙利酸

化合物

丙利酸(英語:Prorenoic acid 或 prorenoate)是一种有机化合物,分子式为C23H32O4,为人工合成甾体抗鹽皮質激素,从未上市销售[1][2][3][4]

丙利酸
臨床資料
其他名稱Prorenoate; 6α,7α-Dihydro-17-hydroxy-3-oxo-3'H-cyclopropa(6,7)-17α-pregna-4,6-diene-21-carboxylic acid
藥物類別英语Drug class抗鹽皮質激素
识别信息
  • 3-[(1R,2R,4R,10R,11S,14S,15R,18S)-15-Hydroxy-10,14-dimethyl-7-oxopentacyclo[9.7.0.02,4.05,10.014,18]octadec-5-en-15-yl]propanoate
CAS号49848-01-3  checkY
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C23H32O4
摩尔质量372.51 g·mol−1
3D模型(JSmol英语JSmol
  • O([H])[C@](CCC(=O)[O-])1CC[C@@]([H])2[C@]1(C)CC[C@@]([H])1[C@](C)3CCC(C=C3[C@@]([H])3C[C@]3([H])[C@@]21[H])=O
  • InChI=1S/C23H32O4/c1-21-7-3-13(24)11-18(21)14-12-15(14)20-16(21)4-8-22(2)17(20)5-9-23(22,27)10-6-19(25)26/h11,14-17,20,27H,3-10,12H2,1-2H3,(H,25,26)/p-1/t14-,15+,16+,17+,20-,21-,22+,23-/m1/s1
  • Key:OHZWNMVYJJTNKU-VAFIVCJBSA-M
丙利酮,也称为丙利酸内酯

参考文献

  1. ^ Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 1036–. ISBN 978-1-4757-2085-3. 
  2. ^ Claire M, Rafestin-Oblin ME, Michaud A, Roth-Meyer C, Corvol P. Mechanism of action of a new antialdosterone compound, prorenone. Endocrinology. April 1979, 104 (4): 1194–1200. PMID 436757. doi:10.1210/endo-104-4-1194. 
  3. ^ Netchitailo P, Delarue C, Perroteau I, Jegou S, Tonon MC, Leroux P, et al. Effect of aldosterone antagonists on mineralocorticoid synthesis in vitro. Inhibition of aldosterone production by prorenoate-K. European Journal of Pharmacology. February 1982, 77 (4): 243–249. PMID 6277668. doi:10.1016/0014-2999(82)90125-x. 
  4. ^ Morton IK, Hall JM. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012: 234–. ISBN 978-94-011-4439-1.