维基百科

促甲状腺激素释放激素受体

位於8號人類染色體的基因

促甲状腺激素释放激素受体（英語：thyrotropin-releasing hormone receptor，TRHR）是一种与三肽促甲状腺激素释放激素结合的G蛋白偶联受体[1][2]。TRHR表达于脑细胞中，在与TRH结合时会激活磷脂酶C增加细胞内的肌醇三磷酸含量。

Thyrotropin-releasing hormone receptor
促甲状腺激素释放激素受体
标识
代号 TRHR; TRH-R
扩展标识 遗传学：188545 鼠基因：98824 同源基因：20707 IUPHAR:  TRH1 ChEMBL: 1810 GeneCards: TRHR Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 7201 22045
Ensembl ENSG00000174417 ENSMUSG00000038760
UniProt P34981 P21761
mRNA序列 NM_003301 NM_013696
蛋白序列 NP_003292 NP_038724
基因位置 Chr 8:
110.1 – 110.13 Mb		 Chr 15:
44.2 – 44.24 Mb
PubMed查询 [1] [2]

参考文献

  1. ^ Yamada M, Monden T, Konaka S, Mori M. Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. Somat. Cell Mol. Genet. 1993, 19 (6): 577–80. PMID 8128317. doi:10.1007/BF01233384. 
  2. ^ Gershengorn MC. Thyrotropin-releasing hormone receptor: cloning and regulation of its expression. Recent Prog. Horm. Res. 1993, 48: 341–63. PMID 8382829. 

延伸阅读

  • Short RE, James LF, Panter KE; et al. Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep.. J. Anim. Sci. 1993, 70 (11): 3498–504. PMID 1459912. 
  • Yamada M, Iwasaki T, Satoh T; et al. Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly.. Neurosci. Lett. 1996, 196 (1-2): 109–12. PMID 7501234. doi:10.1016/0304-3940(95)11861-P. 
  • Hinuma S, Hosoya M, Ogi K; et al. Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene.. Biochim. Biophys. Acta. 1994, 1219 (2): 251–9. PMID 7918619. doi:10.1016/0167-4781(94)90046-9. 
  • Morrison N, Duthie SM, Boyd E; et al. Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization.. Hum. Genet. 1994, 93 (6): 716–8. PMID 8005602. 
  • Yamada M, Monden T, Konaka S, Mori M. Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8.. Somat. Cell Mol. Genet. 1994, 19 (6): 577–80. PMID 8128317. doi:10.1007/BF01233384. 
  • Duthie SM, Taylor PL, Anderson L; et al. Cloning and functional characterisation of the human TRH receptor.. Mol. Cell. Endocrinol. 1994, 95 (1-2): R11–5. PMID 8243797. doi:10.1016/0303-7207(93)90043-J. 
  • Matre V, Karlsen HE, Wright MS; et al. Molecular cloning of a functional human thyrotropin-releasing hormone receptor.. Biochem. Biophys. Res. Commun. 1993, 195 (1): 179–85. PMID 8395824. doi:10.1006/bbrc.1993.2027. 
  • Yamada M, Monden T, Satoh T; et al. Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.. Biochem. Biophys. Res. Commun. 1993, 195 (2): 737–45. PMID 8396925. doi:10.1006/bbrc.1993.2107. 
  • Iwasaki T, Yamada M, Satoh T; et al. Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.. J. Biol. Chem. 1996, 271 (36): 22183–8. PMID 8703031. doi:10.1074/jbc.271.36.22183. 
  • Cook JV, McGregor A, Lee T; et al. A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.. Endocrinology. 1996, 137 (7): 2851–8. PMID 8770906. doi:10.1210/en.137.7.2851. 
  • Collu R, Tang J, Castagné J; et al. A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene.. J. Clin. Endocrinol. Metab. 1997, 82 (5): 1561–5. PMID 9141550. doi:10.1210/jc.82.5.1561. 
  • Petrou C, Tashjian AH. The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles.. Cell. Signal. 1999, 10 (8): 553–9. PMID 9794253. doi:10.1016/S0898-6568(97)00190-3. 
  • Matre V, Høvring PI, Orstavik S; et al. Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.. J. Neurochem. 1999, 72 (1): 40–50. PMID 9886052. doi:10.1046/j.1471-4159.1999.0720040.x. 
  • Kroeger KM, Hanyaloglu AC, Seeber RM; et al. Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.. J. Biol. Chem. 2001, 276 (16): 12736–43. PMID 11278883. doi:10.1074/jbc.M011311200. 
  • Zhu CC, Cook LB, Hinkle PM. Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.. J. Biol. Chem. 2002, 277 (31): 28228–37. PMID 12023974. doi:10.1074/jbc.M204221200. 
  • Hanyaloglu AC, Seeber RM, Kohout TA; et al. Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.. J. Biol. Chem. 2003, 277 (52): 50422–30. PMID 12393857. doi:10.1074/jbc.M209340200. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899. 
  • Cook LB, Zhu CC, Hinkle PM. Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.. Mol. Endocrinol. 2004, 17 (9): 1777–91. PMID 12805411. doi:10.1210/me.2003-0073. 
  • Igarashi-Migitaka J, Yamada S, Hara M; et al. Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas.. Endocr. J. 2004, 50 (4): 459–67. PMID 14599121. doi:10.1507/endocrj.50.459. 
  • Cook LB, Hinkle PM. Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.. Endocrinology. 2004, 145 (7): 3095–100. PMID 15117874. doi:10.1210/en.2004-0304. 

外部链接



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