去甲腎上腺素轉運體

去甲腎上腺素轉運體
識別號
别名	SLC6A2；, NAT1, NET, NET1, SLC6A5, solute carrier family 6 member 2, Norepinephrine transporter, norepinephrine transporter gene
外部ID	OMIM：163970 MGI：1270850 HomoloGene：816 GeneCards：SLC6A2
為以下藥物的標靶
	阿米替林、阿莫沙平、阿托莫西汀、丁氨苯丙酮、西酞普兰、氯米帕明、地昔帕明、去甲文拉法辛、右旋安非他命、度洛西汀、丙咪嗪、左旋米那普倫、洛非帕明、马普替林、馬吲哚、哌甲酯、奈法唑酮、nisoxetine、(RS)-nomifensine、去甲替林、苯乙肼、普罗替林、喹硫平、𫫇泼西汀、西布曲明、他噴他竇、曲米帕明、文拉法辛、zotepine、serdexmethylphenidate chloride、右旋哌甲酯、右旋安非他命、苯丙胺、liafensine、甲基苯丙胺、phentermine hydrochloride、安非拉酮、去甲文拉法辛、馬吲哚、伪麻黄碱、methylphenidate hydrochloride、dasotraline、milnacipran、diethylpropion hydrochloride、bretylium tosylate、desipramine hydrochloride、guanadrel sulfate、imipramine hydrochloride、nefazodone hydrochloride、orphenadrine citrate、phenmetrazine hydrochloride、protriptyline hydrochloride、(+)-pseudoephedrine hydrochloride、venlafaxine hydrochloride
基因位置（人类）
染色体	16號染色體
终止	55,707,645 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	93,728,295 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• dopamine:sodium symporter activity; • neurotransmitter:sodium symporter activity; • norepinephrine:sodium symporter activity; • monoamine transmembrane transporter activity; • 血浆蛋白结合; • symporter activity; • 金屬離子結合; • beta-tubulin binding; • alpha-tubulin binding; • actin binding;
細胞組分	• integral component of membrane; • 细胞膜; • 膜; • 脂筏模型; • neuron projection; • cell surface; • integral component of plasma membrane; • neuronal cell body membrane; • presynaptic membrane;
生物學過程	• dopamine uptake involved in synaptic transmission; • neurotransmitter transport; • response to pain; • monoamine transport; • 化学性突触传递; • norepinephrine transport; • transmembrane transport; • sodium ion transmembrane transport; • norepinephrine uptake; • neuron cellular homeostasis; • 再攝取;
	Sources:Amigo / QuickGO
直系同源
	6530
	20538
	ENSG00000103546
	ENSMUSG00000055368
	P23975
	O55192
	NM_001043; NM_001172501; NM_001172502; NM_001172504
	NM_009209
	NP_001034; NP_001165972; NP_001165973; NP_001165975
	NP_033235
	維基數據
檢視/編輯人類	檢視/編輯小鼠

去甲腎上腺素轉運體（英語：Norepinephrine_transporter，NET），也被稱為溶質載體家族6成員2（英語：solute carrier family 6 member 2，SLC6A2），是由SLC6A2基因編碼的蛋白質。^[6]。NET是一种單胺轉運體（英语：monoamine transporter），負責依賴Na⁺/Cl⁻的胞外去甲腎上腺素再攝取。NET也可轉運多巴胺。對這兩種神经递质的再吸收是調控突觸間隙（英语：synaptic cleft）傳導物濃度的重要機制。

NET以及其他單胺轉運體是不少抗抑鬱劑以及娛樂性藥物的作用對象。過少的NET跟直立不耐症（英语：orthostatic intolerance）相關，過多NET則和ADHD相關。^[7]^[8]

參見

神經遞質轉運體（英语：Neurotransmitter transporter）
Sodium:neurotransmitter symporter（英语：Sodium:neurotransmitter symporter）
溶質載體家族（英语：Solute carrier family）
去甲肾上腺素
單胺轉運體（英语：Monoamine transporter）
直立不耐症（英语：Orthostatic intolerance）
單核苷酸多態性

参考资料

^ 對Solute carrier family 6 member 2起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000103546 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000055368 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0.
^ Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3.
^ Tellioglu T, Robertson D. Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications. Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878.

外部链接

醫學主題詞表（MeSH）：Norepinephrine+transporter

[1] 對Solute carrier family 6 member 2起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000103546 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000055368 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2008212-6] Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0.

[7] Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3.

[pmid14987367-8] Tellioglu T, Robertson D. Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications. Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878.

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