哈尔明

化合物

哈尔明(英語:Harmine,也译为骆驼蓬碱)是一种β-咔啉类生物碱,化学式C13H12N2O。它存在于很多植物中,如骆驼蓬卡披木英语Banisteriopsis caapi[2]它可以可逆地抑制单胺氧化酶A英语monoamine oxidase A(MAO-A),但不抑制MAO-B[3]

Harmine
IUPAC名
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
识别
CAS号 442-51-3  checkY
PubChem 5280953
ChemSpider 4444445
SMILES
 
  • COc1ccc2c(c1)[nH]c3c(C)nccc23
InChI
 
  • 1/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChIKey BXNJHAXVSOCGBA-UHFFFAOYAR
ChEBI 28121
DrugBank DB07919
KEGG C06538
性质
化学式 C13H12N2O
摩尔质量 212.25 g/mol g·mol⁻¹
密度 1.326 g/cm3
熔点 321 °C(594 K)
溶解性 insoluble[1]
溶解性Dimethyl sulfoxide 100mM[1]
溶解性Ethanol 1 mg/mL[1]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ 1.0 1.1 1.2 Harmine - CAS 442-51-3. scbio.de. Santa Cruz Biotechnology, Inc. [27 October 2015]. (原始内容存档于2015-09-24). 
  2. ^ Djamshidian A, et al. Banisteriopsis caapi, a Forgotten Potential Therapy for Parkinson's Disease?. Movement Disorders Clinical Practice. 2015, 3 (1): 19–26. PMC 6353393 . PMID 30713897. doi:10.1002/mdc3.12242. 
  3. ^ Frecska E, Bokor P, Winkelman M. The Therapeutic Potentials of Ayahuasca: Possible Effects against Various Diseases of Civilization. Frontiers in Pharmacology. 2016, 7: 35. PMC 4773875 . PMID 26973523. doi:10.3389/fphar.2016.00035 .