妥拉唑啉
妥拉唑啉是非选择性竞争性α受体拮抗剂。[1]它是治疗周边血管痉挛（如手足发绀）的血管扩张剂，也能与硝普钠配合解除25I-NBOMe[2]、布苯丙胺、Bromodragonfly[3][4]等5-HT2A受体激动剂过量造成的严重血管收缩，避免坏疽。不过，它最常用作消除甲苯噻嗪镇静作用的兽药。[5][6]
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| 臨床資料 | |
|---|---|
| AHFS/Drugs.com | 国际药品名称 |
| 给药途径 | IV |
| ATC碼 | |
| 识别信息 | |
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| CAS号 | 59-98-3  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.408 |
| 化学信息 | |
| 化学式 | C10H12N2 |
| 摩尔质量 | 160.22 g·mol−1 |
| 3D模型（JSmol） | |
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参考资料
- ^ Aronson, J. K. Meyler's side effects of drugs : the international encyclopedia of adverse drug reactions and interactions. Amsterdam: Elsevier Science. 2016. ISBN 978-0-444-53717-1. OCLC 927102885.
Tolazoline is an α2 adrenoceptor antagonist that increases skin blood flow in healthy subjects and has been used to relieve acute vasospasm.
- ^ Human Metabolome Database: Showing metabocard for Tolazoline (HMDB0014935). hmdb.ca. [2022-02-03]. （原始内容存档于2022-02-04）.
- ^ Bowen JS, Davis GB, Kearney TE, Bardin J. Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion. JAMA. March 1983, 249 (11): 1477–9. PMID 6827726. doi:10.1001/jama.1983.03330350053028.
- ^ Thorlacius K, Borna C, Personne M. [Bromo-dragon fly--life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case]. Läkartidningen. 2008, 105 (16): 1199–200. PMID 18522262 （瑞典语）.
- ^ Boothe DM. Anticonvulsant drugs and analeptic agents. Adams HR (编). Veterinary pharmacology and therapeutics. Ames: Iowa State University Press. 2001: 378–9 [2008-09-08]. ISBN 0-8138-1743-9.
- ^ Hall LW, Clarke KW, Trim CM. Principles of sedation, analgesia and premedication. Veterinary anaesthesia. Philadelphia: W.B. Saunders. 2001: 90–1. ISBN 0-7020-2035-4.
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