新丹参内酯

新丹参内酯(英語:Neotanshinlactone 或 Neo-tanshinlactone)是一种多环有机化合物,分子式C17H12O3,属于一种丹参酮类化合物[1],与丹参内酯酯基的方向不同,2004年首次在丹参Salvia miltiorrhiza)中分离[2],此外还存在于毛地黄鼠尾草Salvia digitaloides[3]栗色鼠尾草Salvia castanea[4]等植物中,由于其可特异性作用于ER+MCF-7乳腺癌细胞系引起了研究人员的关注[5]

新丹参内酯
识别
CAS号
PubChem 10264769
SMILES
 
  • O=C1OC2=C(C=CC3=C2C=CC=C3C)C=4OC=C(C14)C
InChI
 
  • 1S/C17H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)20-17(18)14-10(2)8-19-16(13)14/h3-8H,1-2H3
InChIKey LGZUUBFLEYOEEX-UHFFFAOYSA-N
性质
化学式 C17H12O3
摩尔质量 264.28 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ 李兴军,王江,柳红. 丹参脂溶性成分结构优化研究进展. 有机化学. 2023, 42 (2): 471-490. doi:10.6023/cjoc202206054. 
  2. ^ Wang, X; Bastow, KF; Sun, CM; Lin, YL; Yu, HJ; Don, MJ; Wu, TS; Nakamura, S; Lee, KH. Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.. Journal of medicinal chemistry. 2004-11-04, 47 (23): 5816–9. PMID 15509181. doi:10.1021/jm040112r. 
  3. ^ Xu, G; Yang, J; Wang, YY; Peng, LY; Yang, XW; Pan, ZH; Liu, ED; Li, Y; Zhao, QS. Diterpenoid constituents of the roots of Salvia digitaloides.. Journal of agricultural and food chemistry. 2010-12-08, 58 (23): 12157–61. PMID 21073172. doi:10.1021/jf103366g. 
  4. ^ Pan, ZH; Li, Y; Wu, XD; He, J; Chen, XQ; Xu, G; Peng, LY; Zhao, QS. Norditerpenoids from Salvia castanea Diels f. pubescens.. Fitoterapia. 2012-09, 83 (6): 1072–5. PMID 22609685. doi:10.1016/j.fitote.2012.05.005. 
  5. ^ Wanjun Lin, Jiajun Huang, Xiaolin Liao; et al. Neo-tanshinlactone selectively inhibits the proliferation of estrogen receptor positive breast cancer cells through transcriptional down-regulation of estrogen receptor alpha. Pharmacological Research. 2016, 111: 849-858. doi:10.1016/j.phrs.2016.07.044.