白细胞介素-11

IL11
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4MHL
識別號
别名	IL11；, AGIF, IL-11, interleukin 11
外部ID	OMIM：147681 MGI：107613 HomoloGene：535 GeneCards：IL11
基因位置（人类）
染色体	19號染色體
终止	55,370,463 bp
基因位置（小鼠）
染色体	小鼠7号染色体
终止	4,785,858 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• 生長因子活性; • interleukin-11 receptor binding; • 細胞因子活性; • 血浆蛋白结合;
細胞組分	• 細胞質; • 細胞外空間; • 細胞外區域;
生物學過程	• 內皮細胞凋亡過程的負調控; • positive regulation of MAPK cascade; • positive regulation of peptidyl-serine phosphorylation; • B cell differentiation; • positive regulation of transcription by RNA polymerase II; • negative regulation of hormone secretion; • positive regulation of peptidyl-tyrosine phosphorylation; • fat cell differentiation; • positive regulation of cell population proliferation; • regulation of complement-dependent cytotoxicity; • megakaryocyte differentiation; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway; • cardiovascular fibrosis;
	Sources:Amigo / QuickGO
直系同源
	3589
	16156
	ENSG00000095752
	ENSMUSG00000004371
	P20809
	P47873
	NM_001267718; NM_000641
	NM_008350; NM_001290423
	NP_000632; NP_001254647
	NP_001277352; NP_032376
	維基數據
檢視/編輯人類	檢視/編輯小鼠

白细胞介素-11（英語：Interleukin-11，缩写IL-11，也称为“脂肪形成抑制因子”，adipogenesis inhibitory factor，缩写AGIF^[5]）是一种细胞因子，由人类基因 IL11 编码^[6]，与细胞表面的白细胞介素-11受体结合发挥作用^[7]^[8]。

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000095752 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000004371 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kawashima I, Ohsumi J, Mita-Honjo K, Shimoda-Takano K, Ishikawa H, Sakakibara S, Miyadai K, Takiguchi Y. Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Letters. June 1991, 283 (2): 199–202. PMID 1828438. S2CID 1385397. doi:10.1016/0014-5793(91)80587-S  .
^ McKinley D, Wu Q, Yang-Feng T, Yang YC. Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). Genomics. July 1992, 13 (3): 814–9. PMID 1386338. doi:10.1016/0888-7543(92)90158-O.
^ Nandurkar HH, Robb L, Tarlinton D, Barnett L, Köntgen F, Begley CG. Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. Blood. September 1997, 90 (6): 2148–59. PMID 9310465. doi:10.1182/blood.V90.6.2148  .
^ Brischoux-Boucher E, Trimouille A, Baujat G, Goldenberg A, Schaefer E, Guichard B, Hannequin P, Paternoster G, Baer S, Cabrol C, Weber E, Godfrin G, Lenoir M, Lacombe D, Collet C, Van Maldergem L. IL11RA-related Crouzon-like autosomal recessive craniosynostosis in 10 new patients: Resemblances and differences. Clinical Genetics. October 2018, 94 (3–4): 373–380. PMID 29926465. S2CID 49339003. doi:10.1111/cge.13409.

外部链接

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000095752 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000004371 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1828438-5] Kawashima I, Ohsumi J, Mita-Honjo K, Shimoda-Takano K, Ishikawa H, Sakakibara S, Miyadai K, Takiguchi Y. Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Letters. June 1991, 283 (2): 199–202. PMID 1828438. S2CID 1385397. doi:10.1016/0014-5793(91)80587-S  .

[pmid1386338-6] McKinley D, Wu Q, Yang-Feng T, Yang YC. Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). Genomics. July 1992, 13 (3): 814–9. PMID 1386338. doi:10.1016/0888-7543(92)90158-O.

[7] Nandurkar HH, Robb L, Tarlinton D, Barnett L, Köntgen F, Begley CG. Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. Blood. September 1997, 90 (6): 2148–59. PMID 9310465. doi:10.1182/blood.V90.6.2148  .

[8] Brischoux-Boucher E, Trimouille A, Baujat G, Goldenberg A, Schaefer E, Guichard B, Hannequin P, Paternoster G, Baer S, Cabrol C, Weber E, Godfrin G, Lenoir M, Lacombe D, Collet C, Van Maldergem L. IL11RA-related Crouzon-like autosomal recessive craniosynostosis in 10 new patients: Resemblances and differences. Clinical Genetics. October 2018, 94 (3–4): 373–380. PMID 29926465. S2CID 49339003. doi:10.1111/cge.13409.

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