羟甲芬太尼

羟甲芬太尼(英語:Ohmefentanyl,也称为β-羟基-3-甲基芬太尼β-hydroxy-3-methylfentanyl,缩写OMF,研发代号:RTI-4614-4)是一种含氮有机化合物,化学式C23H20N2O2,属于芬太尼衍生物[1],能作为類阿片镇痛药[2][3]

羟甲芬太尼
臨床資料
ATC碼
  • 未分配
法律規範狀態
法律規範
识别信息
  • N-[1-(2-hydroxy-2-phenylethyl)-3-methylpiperidin-4-yl]-N-phenylpropanamide
CAS号78995-14-9  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C23H30N2O2
摩尔质量366.51 g·mol−1
3D模型(JSmol英语JSmol
  • CCC(=O)N(c1ccccc1)C2CCN(CC2C)CC(O)c3ccccc3
  • InChI=1S/C23H30N2O2/c1-3-23(27)25(20-12-8-5-9-13-20)21-14-15-24(16-18(21)2)17-22(26)19-10-6-4-7-11-19/h4-13,18,21-22,26H,3,14-17H2,1-2H3 checkY
  • Key:FRPRNNRJTCONEC-UHFFFAOYSA-N checkY

参考文献

  1. ^ Rothman RB, Xu H, Seggel M, Jacobson AE, Rice KC, Brine GA, Carroll FI. RTI-4614-4: an analog of (+)-cis-3-methylfentanyl with a 27,000-fold binding selectivity for mu versus delta opioid binding sites. Life Sciences. April 1991, 48 (23): PL111–PL116. PMID 1646357. doi:10.1016/0024-3205(91)90346-D. 
  2. ^ Brine GA, Stark PA, Liu Y, Carroll FI, Singh P, Xu H, Rothman RB. Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities. Journal of Medicinal Chemistry. April 1995, 38 (9): 1547–1557. PMID 7739013. doi:10.1021/jm00009a015. 
  3. ^ Wang ZX, Zhu YC, Jin WQ, Chen XJ, Chen J, Ji RY, Chi ZQ. Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics. Journal of Medicinal Chemistry. September 1995, 38 (18): 3652–3659. PMID 7658453. doi:10.1021/jm00018a026. 

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