血小板衍生生長因子受體
血小板衍生生長因子受體（Platelet-derived growth factor receptors，PDGF-R）為血小板衍生生長因子（PDGF）蛋白質家族的受體，位於細胞膜表面，屬於酪胺酸激酶受體的一種。PDGF的次單元A和次單元B在調控細胞增殖、分化、生長、發育上扮演相當重要的角色。如果調控不正常，可能會引發癌症等多種疾病。[2]
| 血小板衍生生長因子受體的α鏈 | |
|---|---|
| 識別 | |
| 符號 | PDGFRA |
| Entrez | 5156 |
| HUGO | 8803 |
| OMIM | 173490 |
| RefSeq | NM_006206 |
| UniProt | P16234 |
| 其他資料 | |
| 基因座 | 4 q12 |
| 血小板衍生生長因子受體的β鏈 | |
|---|---|
| |
| Ribbon image of two molecules of human PDGF receptor beta (yellow and magenta) in complex with dimeric PDGF-B (cyan and green).[1] | |
| 識別 | |
| 符號 | PDGFRB |
| 替換符號 | PDGFR |
| Entrez | 5159 |
| HUGO | 8804 |
| OMIM | 173410 |
| RefSeq | NM_002609 |
| UniProt | P09619 |
| 其他資料 | |
| 基因座 | 5 q31-q32 |
PDGF-R有兩種型態，分別為A和B，兩種型態來自於不同基因。[3]由於PDRF-R必須由兩者結合成為雙體之後才能作用，因此PDGFRA和PDGFRB可以互相組合或自我組合為均聚物（homodimerizes，即A配A、B配B）或雜二聚物（heterodimerizes，即A配B）[4]
參見
參考資料
- ^ PDB 3MJG; Shim, Ann Hye-Ryong; Liu, Heli; Focia, Pamela J.; Chen, Xiaoyan; Lin, P. Charles; He, Xiaolin. Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proceedings of the National Academy of Sciences. 2010, 107 (25): 11307–12. ISSN 0027-8424. PMC 2895058
. PMID 20534510. doi:10.1073/pnas.1000806107.; rendered using PyMOL （页面存档备份，存于互联网档案馆）.
- ^ Williams LT. Signal transduction by the platelet-derived growth factor receptor. Science. March 1989, 243 (4898): 1564–70. PMID 2538922. doi:10.1126/science.2538922.
- ^ Heldin CH, Westermark B. Platelet-derived growth factor: three isoforms and two receptor types. Trends Genet. April 1989, 5 (4): 108–11. PMID 2543106. doi:10.1016/0168-9525(89)90040-1.
- ^ Heldin CH, Ostman A, Eriksson A, Siegbahn A, Claesson-Welsh L, Westermark B. Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes. Kidney Int. March 1992, 41 (3): 571–4. PMID 1315403. doi:10.1038/ki.1992.84.
