赛克利嗪

赛克利嗪
臨床資料
商品名（英语：Drug nomenclature）	Marezine, Valoid, Nausicalm, others
AHFS/Drugs.com	消费者药物信息
懷孕分級	澳: A ; ;
给药途径	口服、IM、IV
ATC碼	R06AE03 (WHO) ;
法律規範狀態
法律規範	澳：限药剂师（S3）; 英：药房药品; 美：OTC; 荷兰：OTC;
藥物動力學數據
药物代谢	N-脱甲基成二苯甲基哌嗪（英语：norcyclizine）
生物半衰期	20小时
识别信息
	IUPAC命名法 1-benzhydryl-4-methyl-piperazine; ;
CAS号	82-92-8
PubChem CID	6726;
IUPHAR/BPS	7151;
DrugBank	DB01176 ;
ChemSpider	6470 ;
UNII	QRW9FCR9P2;
KEGG	D03621 ;
ChEBI	CHEBI:3994 ;
ChEMBL	ChEMBL648 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID4022864 ;
ECHA InfoCard	100.001.314
化学信息
化学式	C18H22N2
摩尔质量	266.39 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CN(CC1)CCN1C(C2=CC=CC=C2)C3=CC=CC=C3;
	InChI InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3 ; Key:UVKZSORBKUEBAZ-UHFFFAOYSA-N ;

赛克利嗪（英语：Cyclizine）是用于治疗和预防晕车造成的恶心、呕吐、头晕的药物，^[2]也可用于治疗全身麻醉或使用阿片类后导致的恶心。^[2]^[3]它通过口服、直肠（英语：Rectal administration）或静脉给药。^[3]^[4]

赛克利嗪常见的副作用包括嗜睡、口干、便秘、视力问题，更严重的副作用则包括低血压和尿潴留。^[5]一般不推荐儿童和青光眼患者使用赛克利嗪。^[2]^[6]赛克利嗪看起来对孕妇安全，但这尚未得到充分研究。^[7]它属于抗胆碱剂和抗组织胺药。^[3]^[6]

赛克利嗪于1947年被发现。^[8]它是世界卫生组织基本药物，^[9]在美国是非处方药。^[6]

参考资料

^ DrugBank: Cyclizine. Pharmacology: metabolism. DrugBank Database. [5 January 2016]. （原始内容存档于30 January 2016）.
^ ^2.0 ^2.1 ^2.2 Cyclizine 50mg Tablets - Summary of Product Characteristics (SPC) - (eMC). www.medicines.org.uk. 27 March 2015 [13 December 2016]. （原始内容存档于20 December 2016）.
^ ^3.0 ^3.1 ^3.2 Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. Elsevier Health Sciences. 2015: 218. ISBN 9781455749898. （原始内容存档于2016-12-20）.
^ World Health Organization. World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ Cyclizine Side Effects in Detail - Drugs.com. www.drugs.com. [13 December 2016]. （原始内容存档于21 December 2016）.
^ ^6.0 ^6.1 ^6.2 Cyclizine: Indications, Side Effects, Warnings - Drugs.com. www.drugs.com. [13 December 2016]. （原始内容存档于21 December 2016）.
^ Cyclizine Use During Pregnancy | Drugs.com. www.drugs.com. [13 December 2016]. （原始内容存档于21 December 2016）.
^ Williams P. The story of the Wellcome Trust : unlocking Sir Henry's legacy to medical research. Hindringham: JJG. 2010: 14. ISBN 9781899163922. （原始内容存档于2016-12-20）.
^ World Health Organization. World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. hdl:10665/345533  . WHO/MHP/HPS/EML/2021.02.

外部链接

Cyclizine. Drug Information Portal. U.S. National Library of Medicine. [2023-10-22]. （原始内容存档于2022-10-27）.

[1] DrugBank: Cyclizine. Pharmacology: metabolism. DrugBank Database. [5 January 2016]. （原始内容存档于30 January 2016）.

[ERC2015-2] 2.0 ^2.1 ^2.2 Cyclizine 50mg Tablets - Summary of Product Characteristics (SPC) - (eMC). www.medicines.org.uk. 27 March 2015 [13 December 2016]. （原始内容存档于20 December 2016）.

[Fe2015-3] 3.0 ^3.1 ^3.2 Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. Elsevier Health Sciences. 2015: 218. ISBN 9781455749898. （原始内容存档于2016-12-20）.

[WHO21st-4] World Health Organization. World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[SFX2016-5] Cyclizine Side Effects in Detail - Drugs.com. www.drugs.com. [13 December 2016]. （原始内容存档于21 December 2016）.

[CDI2016-6] 6.0 ^6.1 ^6.2 Cyclizine: Indications, Side Effects, Warnings - Drugs.com. www.drugs.com. [13 December 2016]. （原始内容存档于21 December 2016）.

[7] Cyclizine Use During Pregnancy | Drugs.com. www.drugs.com. [13 December 2016]. （原始内容存档于21 December 2016）.

[8] Williams P. The story of the Wellcome Trust : unlocking Sir Henry's legacy to medical research. Hindringham: JJG. 2010: 14. ISBN 9781899163922. （原始内容存档于2016-12-20）.

[WHO22nd-9] World Health Organization. World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. hdl:10665/345533  . WHO/MHP/HPS/EML/2021.02.

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