高鉀血症

高鉀血症拉丁語hyperkalemiahyperkalaemia),即生物體內中含鉀離子(K+)含量過多[1]。人體 95%的鉀元素位於細胞內,僅 5%位於血液中,而鈉鉀泵正是保持此濃度差的主要機制。血清正常血鉀值介於 3.5至 5.5 mEq/L之間,血漿正常血鉀值則介於 3.5至 5.0 mEq/L之間,若高於正常值則稱為高鉀血症[2][3]。外科学上,血清钾浓度超过5.5mmol/L[4]或5.0mmol/L[5][6]即为高钾血症。[7]通常高鉀血症不會有症狀[1],但可能引發心悸肌肉疼痛肌肉無力英语muscle weakness,或感覺麻木(拉丁語Paresthesia)等[1][8]。嚴重時將引發心律不整,進一步導致病患死亡[1][2]

高鉀血症
高血鉀症患者的心電圖
类型mineral metabolism disease[*]電解質不平衡
分类和外部资源
醫學專科重症醫學腎臟科
ICD-115C76
ICD-10E87.5
ICD-9-CM276.7
DiseasesDB6242
MedlinePlus001179
eMedicineemerg/261
MeSHD006947
[编辑此条目的维基数据]

病因及诊断

高钾血症最常見的原因包含腎功能衰竭醛固酮過低英语hypoaldosteronism,或横纹肌溶解症等等[1]。某些藥物包含螺内酯非甾体抗炎药,以及血管紧张肽I转化酶抑制剂(ACEI)也會造成血鉀提升[1]

高鉀血症能以血鉀濃度分為輕度(5.5-5.9 mmol/L)、中度(6.0-6.4 mmol/L),及重度(>6.5 mmol/L)[2]。劑量高時甚至能以心电图偵測[2]。檢驗必須排除因採血過程破壞細胞所造成的假性高血鉀[1][8]

症狀

症狀不明顯,但一般包括身體不適、心悸、及肌肉無力。輕微的過度換氣可能是代謝性酸中毒──高鉀血症的症狀之一──引起的補償機制。然而此種情形通常僅在血液篩檢、或是心律不整等併發症產生時才得以偵測。

在問診時,醫生會聚焦於腎臟疾病及用藥上,因為此二者皆為此症主因。然而若伴隨腹痛低血糖症及色素大量沉著,則病患可能同時患有其他自體免疫性疾病愛迪生氏病

治疗

立即停止外源性钾摄入和针对可逆病因的治疗通常是高钾血症处置的第一步[9],建議進行低鉀飲食[1]

葡萄糖酸钙

由于钙离子对于钾离子有对抗作用,若心電圖發生變化,可给予葡萄糖酸钙以对抗心率失常[1][2]

联用葡萄糖和胰岛素

静脉注射胰岛素葡萄糖是有证据支持的治疗紧急高钾血症的一线疗法之一。[10]该方法促进钾离子向细胞内的转运从而降低血钾。[11]低血糖是该疗法可能的并发症。[12]

碳酸氢钠

阳离子交换树脂

阳离子交换树脂英语polystyrene sulfonate用于通过加速肠道中钾的流失来治疗高钾血症,特别是在尿量不足或透析之前的情况下。[13]负载有钠或钙的树脂倾向于和胃肠液中的钾离子结合,释放出钠或钙离子,随后树脂随粪便排除,从而实现降低血钾的目的。在施用的同时需要考虑钠或钙超载的风险。[13]亦有观点认为该方法效果太差而不推荐使用。[14]

其它药物

呋塞米沙丁胺醇[來源請求]

透析

透析包括腹膜透析和血液透析,通常在上述方法均无效或病症严重的情况下使用[15][16],或为最有效的方式[2]

流行病学

正常個體很少會發生高血鉀的狀況[17],但在醫院病患中發生的機率高達1%至 2.5%[8],且會將死亡風險拉高十倍以上[8][17]

相關介紹影片

另见

參考文獻

  1. ^ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Lehnhardt, A; Kemper, MJ. Pathogenesis, diagnosis and management of hyperkalemia.. Pediatric nephrology (Berlin, Germany). March 2011, 26 (3): 377–84. PMC 3061004 . PMID 21181208. doi:10.1007/s00467-010-1699-3. 
  2. ^ 2.0 2.1 2.2 2.3 2.4 2.5 Soar, J; Perkins, GD; Abbas, G; Alfonzo, A; Barelli, A; Bierens, JJ; Brugger, H; Deakin, CD; Dunning, J; Georgiou, M; Handley, AJ; Lockey, DJ; Paal, P; Sandroni, C; Thies, KC; Zideman, DA; Nolan, JP. European Resuscitation Council Guidelines for Resuscitation 2010 Section 8. Cardiac arrest in special circumstances: Electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution.. Resuscitation. October 2010, 81 (10): 1400–33. PMID 20956045. doi:10.1016/j.resuscitation.2010.08.015. 
  3. ^ Pathy, M.S. John. Principles and practice of geriatric medicine 4. Chichester [u.a.]: Wiley. 2006: Appendix [2017-03-17]. ISBN 9780470090558. (原始内容存档于2016-10-01). 
  4. ^ 吴梦超. 外科学. 北京: 人民卫生出版社. 2018: 14. ISBN 978-7-117-26639-0. 
  5. ^ Townsend, Courtney M. (编). Shock, Electrolytes, and Fluid. Sabiston textbook of surgery: the biological basis of modern surgical practice 21st. St. Louis, Missouri: Elsevier. 2022: 86. ISBN 978-0-323-64062-6. Hyperkalemia is defined as [K+] of more than 5.0 mmol/L. 
  6. ^ Bansal, Shweta; Pergola, Pablo E. Current Management of Hyperkalemia in Patients on Dialysis. Kidney International Reports. 2020-06, 5 (6). doi:10.1016/j.ekir.2020.02.1028 (英语). generally defined as serum potassium (K+) concentrations of >5.0 mmol/l 
  7. ^ Simon, Leslie V.; Hashmi, Muhammad F.; Farrell, Mitchell W. Hyperkalemia. StatPearls. Treasure Island (FL): StatPearls Publishing. 2024. PMID 29261936. Hyperkalemia is defined as a serum or plasma potassium level above the upper limits of normal, usually greater than 5.0 mEq/L to 5.5 mEq/L 
  8. ^ 8.0 8.1 8.2 8.3 McDonald, TJ; Oram, RA; Vaidya, B. Investigating hyperkalaemia in adults.. BMJ (Clinical research ed.). 20 October 2015, 351: h4762. PMID 26487322. 
  9. ^ Simon, Leslie V.; Hashmi, Muhammad F.; Farrell, Mitchell W. Hyperkalemia. StatPearls. Treasure Island (FL): StatPearls Publishing. 2024. PMID 29261936. Exogenous sources of potassium should be immediately discontinued. 
  10. ^ Mahoney, BA; Smith, WA; Lo, DS; Tsoi, K; Tonelli, M; Clase, CM. Emergency interventions for hyperkalaemia.. The Cochrane database of systematic reviews. 18 April 2005, (2): CD003235. PMID 15846652. doi:10.1002/14651858.CD003235.pub2. 
  11. ^ Sterns, Richard H.; Grieff, Marvin; Bernstein, Paul L. Treatment of hyperkalemia: something old, something new. Kidney International. 2016-03, 89 (3). doi:10.1016/j.kint.2015.11.018 (英语). 
  12. ^ Moussavi, Kayvan; Fitter, Scott; Gabrielson, Stephen Walter; Koyfman, Alex; Long, Brit. Management of Hyperkalemia With Insulin and Glucose: Pearls for the Emergency Clinician. The Journal of Emergency Medicine. 2019-07, 57 (1). doi:10.1016/j.jemermed.2019.03.043 (英语). 
  13. ^ 13.0 13.1 O'Shaughnessy, Kevin M. Kidney and genitourinary tract. Clinical Pharmacology. Elsevier. 2012: 452–466. ISBN 978-0-7020-4084-9. doi:10.1016/b978-0-7020-4084-9.00066-5 (英语). 
  14. ^ Kamel, Kamel S.; Lin, Shih-Hua; Halperin, Mitchell L. Clinical Disorders of Hyperkalemia. Seldin and Giebisch's The Kidney. Elsevier. 2008: 1387–1405. ISBN 978-0-12-088488-9. doi:10.1016/b978-012088488-9.50052-8 (英语). Thus, there is little if any benefit of using resins for the treatment of acute hyperkalemia and little benefit of adding resins to cathartics in the setting of chronic hyperkalemia. 
  15. ^ Hyperkalemia Treatment & Management: Approach Considerations, Initial Emergency Management, Pharmacologic Therapy and Dialysis. 2023-10-16. Any patient with significantly elevated potassium levels should undergo dialysis 
  16. ^ Bansal, Shweta; Pergola, Pablo E. Current Management of Hyperkalemia in Patients on Dialysis. Kidney International Reports. 2020-06, 5 (6). PMC 7270720 . PMID 32518860. doi:10.1016/j.ekir.2020.02.1028 (英语). 
  17. ^ 17.0 17.1 Kovesdy, CP. Updates in hyperkalemia: Outcomes and therapeutic strategies.. Reviews in endocrine & metabolic disorders. 6 September 2016. PMID 27600582. doi:10.1007/s11154-016-9384-x. 

外部連結