ABT-418
化合物
ABT-418是一种有机化合物，化学式为C9H14N2O，由美國雅培开发，可用作益智藥和抗焦慮藥。[1][2][3][4][5]
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| CAS号 | 147402-53-7  |
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| 化学信息 | |
| 化学式 | C9H14N2O |
| 摩尔质量 | 166.22 |
| 3D模型（JSmol） | |
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参考文献
- ^ Arneric SP, Sullivan JP, Briggs CA, Donnelly-Roberts D, Anderson DJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization. The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 310–318 [2023-11-09]. PMID 7518514. （原始内容存档于2005-05-07）.
- ^ Decker MW, Brioni JD, Sullivan JP, Buckley MJ, Radek RJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 319–328 [2023-11-09]. PMID 7913497. （原始内容存档于2005-05-07）.
- ^ Brioni JD, O'Neill AB, Kim DJ, Buckley MJ, Decker MW, Arneric SP. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. The Journal of Pharmacology and Experimental Therapeutics. October 1994, 271 (1): 353–361 [2023-11-09]. PMID 7965735. （原始内容存档于2009-09-05）.
- ^ Prendergast MA, Terry AV, Jackson WJ, Marsh KC, Decker MW, Arneric SP, Buccafusco JJ. Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418. Psychopharmacology. April 1997, 130 (3): 276–284. PMID 9151363. S2CID 34377165. doi:10.1007/s002130050240.
- ^ Dallanoce C, Magrone P, Matera C, Lo Presti L, De Amici M, Riganti L, et al. Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. European Journal of Medicinal Chemistry. December 2010, 45 (12): 5594–5601. PMID 20932609. doi:10.1016/j.ejmech.2010.09.009.