CD34

CD34
識別號
别名	CD34；, entrez:947, CD34 molecule
外部ID	OMIM：142230 MGI：88329 HomoloGene：1343 GeneCards：CD34
基因位置（人类）
染色体	1號染色體
终止	207,911,402 bp
基因位置（小鼠）
染色体	小鼠1号染色体
终止	194,643,587 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 转录因子结合; • sulfate binding; • carbohydrate binding;
細胞組分	• 細胞質; • integral component of membrane; • 膜; • 细胞膜; • integral component of plasma membrane; • 細胞外區域; • cell surface; • basal plasma membrane; • glomerular endothelium fenestra; • apical plasma membrane; • intercellular bridge; • 细胞质的核周区域; • 溶酶体; • external side of plasma membrane; • cell periphery;
生物學過程	• extracellular exosome assembly; • stem cell proliferation; • positive regulation of interleukin-10 production; • cell motility; • negative regulation of blood coagulation; • metanephric glomerular mesangial cell differentiation; • 旁分泌; • hematopoietic stem cell proliferation; • positive regulation of granulocyte colony-stimulating factor production; • negative regulation of gene expression; • positive regulation of angiogenesis; • 血压调节; • vascular wound healing; • positive regulation of gene expression; • glomerular filtration; • negative regulation of nitric oxide biosynthetic process; • 細胞粘附; • endothelial cell proliferation; • mesangial cell-matrix adhesion; • tissue homeostasis; • positive regulation of vasculogenesis; • endothelium development; • regulation of immune response; • negative regulation of cellular response to heat; • positive regulation of transforming growth factor beta production; • glomerular endothelium development; • 腫瘤壞死因子產生的負調控; • cell-matrix adhesion; • 細胞增殖; • positive regulation of odontogenesis; • negative regulation of cellular response to hypoxia; • leukocyte migration; • 訊息傳遞; • 分化轉移; • negative regulation of neuron death; • cell-cell adhesion; • 造血作用;
	Sources:Amigo / QuickGO
直系同源
	947
	12490
	ENSG00000174059
	ENSMUSG00000016494
	P28906
	Q64314
	NM_001025109; NM_001773
	NM_001111059; NM_133654
	NP_001020280; NP_001764
	NP_001104529; NP_598415
	維基數據
檢視/編輯人類	檢視/編輯小鼠

CD34（小鼠、大鼠的同源蛋白寫作Cd34），是一類分化簇（Cluster of differentiation, CD）分子，在人體內由CD34基因編碼，主要用來鑑定造血幹細胞（HSC）等成體幹細胞^[5]^[6]^[7]。CD34化學本質爲糖蛋白，正常情況下位於細胞膜表面，功能包括參與細胞—細胞間黏附和細胞—細胞外基質（ECM）黏附。

功能

CD34最早於20世紀80年代由兩個課題組同時獨立發現，最初是用來鑑定一類造血幹細胞（CD34+陽性）。现在，是否表達CD34也是分離、鑑別造血幹細胞及其亚群（subpopulation）的一項重要指標^[8]^[9]^[10]^[11]^[12]^[13]。CD34为单跨膜的黏液素（Mucin）類糖蛋白，通常分佈於細胞膜表面^[14]。CD34功能複雜，至今CD34的功能仍然未完全闡明，已知的CD34分子功能主要是參與細胞黏附^[15]^[16]。

分佈

CD34蛋白主要表達於造血幹細胞和造血祖細胞中，同時，血管內皮細胞、一部分間充質幹細胞（MSC）也表達CD34^[17]。CD34在臍帶和骨髓中表達強度相對較高^[18]。

參見

分化簇（CD）
CD44

參考

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000174059 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: CD34 CD34 molecule. （原始内容存档于2019-09-24）.
^ Simmons DL, Satterthwaite AB, Tenen DG, Seed B. Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells. Journal of Immunology. Jan 1992, 148 (1): 267–71 [2018-02-14]. PMID 1370171. （原始内容存档于2008-06-06）.
^ Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG. Structure of the gene encoding CD34, a human hematopoietic stem cell antigen. Genomics. Apr 1992, 12 (4): 788–94. PMID 1374051. doi:10.1016/0888-7543(92)90310-O.
^ Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH. Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. Journal of Immunology. 1984, 133 (1): 157–65. PMID 6586833.
^ Tindle RW. Nichols R. Chan L. Campana D. Birnie GD. A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B, non-T lymphoblasts in acute leukaemia and CGL blast crises, and react with immature cells in normal bone marrow. Leukaemia Research. 1985, 9: 1–9. doi:10.1016/0145-2126(85)90016-5.
^ Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. BI-3C5 (CD34) defines multipotential and lineage restricted progenitor cells and their leukaemic counterparts .. In 'Leucocyte typing 111: White cell differentiation antigens. Oxford University Press, 654-655. 1987.
^ Loken M. Shah V. Civin CI.. Characterization of myeloid antigens on human bone marrow using multicolour immunofluorescence. In: McMichael, Leucocyte Typing III:White cell differentiation antigens.Oxford University Press 630-635. 1987.
^ Furness SG, McNagny K. Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Immunologic Research. 2006, 34 (1): 13–32. PMID 16720896. doi:10.1385/IR:34:1:13.
^ Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, Thamaraikannan P, Abraham S. Autologous Multiple Injections of in Vitro Expanded Autologous Bone Marrow Stem Cells For Cervical Level Spinal Cord Injury - A Case Report. Journal of Stem Cells and Regenerative Medicine. 2010 [2018-02-14]. （原始内容存档于2018-04-10）.
^ Nielsen JS, McNagny KM. Novel functions of the CD34 family. Journal of Cell Science. Nov 2008, 121 (Pt 22): 3683–92. PMID 18987355. doi:10.1242/jcs.037507.
^ Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM. CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution. Immunity. Jan 2005, 22 (1): 43–57. PMID 15664158. doi:10.1016/j.immuni.2004.11.014.
^ Strilić B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E. The molecular basis of vascular lumen formation in the developing mouse aorta. Developmental Cell. Oct 2009, 17 (4): 505–15. PMID 19853564. doi:10.1016/j.devcel.2009.08.011.
^ Ogawa M, Tajima F, Ito T, Sato T, Laver JH, Deguchi T. CD34 expression by murine hematopoietic stem cells. Developmental changes and kinetic alterations. Annals of the New York Academy of Sciences. Jun 2001, 938: 139–45. Bibcode:2001NYASA.938..139O. PMID 11458501. doi:10.1111/j.1749-6632.2001.tb03583.x.
^ Sidney LE, Branch MJ, Dunphy SE, Dua HS, Hopkinson A. Concise review: evidence for CD34 as a common marker for diverse progenitors. Stem Cells. Jun 2014, 32 (6): 1380–9. PMC 4260088  . PMID 24497003. doi:10.1002/stem.1661.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000174059 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Entrez Gene: CD34 CD34 molecule. （原始内容存档于2019-09-24）.

[pmid1370171-6] Simmons DL, Satterthwaite AB, Tenen DG, Seed B. Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells. Journal of Immunology. Jan 1992, 148 (1): 267–71 [2018-02-14]. PMID 1370171. （原始内容存档于2008-06-06）.

[pmid1374051-7] Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG. Structure of the gene encoding CD34, a human hematopoietic stem cell antigen. Genomics. Apr 1992, 12 (4): 788–94. PMID 1374051. doi:10.1016/0888-7543(92)90310-O.

[8] Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH. Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. Journal of Immunology. 1984, 133 (1): 157–65. PMID 6586833.

[9] Tindle RW. Nichols R. Chan L. Campana D. Birnie GD. A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B, non-T lymphoblasts in acute leukaemia and CGL blast crises, and react with immature cells in normal bone marrow. Leukaemia Research. 1985, 9: 1–9. doi:10.1016/0145-2126(85)90016-5.

[10] Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. BI-3C5 (CD34) defines multipotential and lineage restricted progenitor cells and their leukaemic counterparts .. In 'Leucocyte typing 111: White cell differentiation antigens. Oxford University Press, 654-655. 1987.

[11] Loken M. Shah V. Civin CI.. Characterization of myeloid antigens on human bone marrow using multicolour immunofluorescence. In: McMichael, Leucocyte Typing III:White cell differentiation antigens.Oxford University Press 630-635. 1987.

[pmid16720896-12] Furness SG, McNagny K. Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Immunologic Research. 2006, 34 (1): 13–32. PMID 16720896. doi:10.1385/IR:34:1:13.

[Srivastava_2010-13] Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, Thamaraikannan P, Abraham S. Autologous Multiple Injections of in Vitro Expanded Autologous Bone Marrow Stem Cells For Cervical Level Spinal Cord Injury - A Case Report. Journal of Stem Cells and Regenerative Medicine. 2010 [2018-02-14]. （原始内容存档于2018-04-10）.

[pmid18987355-14] Nielsen JS, McNagny KM. Novel functions of the CD34 family. Journal of Cell Science. Nov 2008, 121 (Pt 22): 3683–92. PMID 18987355. doi:10.1242/jcs.037507.

[pmid15664158-15] Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM. CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution. Immunity. Jan 2005, 22 (1): 43–57. PMID 15664158. doi:10.1016/j.immuni.2004.11.014.

[pmid19853564-16] Strilić B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E. The molecular basis of vascular lumen formation in the developing mouse aorta. Developmental Cell. Oct 2009, 17 (4): 505–15. PMID 19853564. doi:10.1016/j.devcel.2009.08.011.

[17] Ogawa M, Tajima F, Ito T, Sato T, Laver JH, Deguchi T. CD34 expression by murine hematopoietic stem cells. Developmental changes and kinetic alterations. Annals of the New York Academy of Sciences. Jun 2001, 938: 139–45. Bibcode:2001NYASA.938..139O. PMID 11458501. doi:10.1111/j.1749-6632.2001.tb03583.x.

[18] Sidney LE, Branch MJ, Dunphy SE, Dua HS, Hopkinson A. Concise review: evidence for CD34 as a common marker for diverse progenitors. Stem Cells. Jun 2014, 32 (6): 1380–9. PMC 4260088  . PMID 24497003. doi:10.1002/stem.1661.

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