CGP-7930

化合物

CGP-7930(化学名: 2,6-二叔丁基-4-(3-羟基-2,2-二甲基丙基)-苯酚2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol)是一种有机化合物,是GABAB受体的正向别构调节剂,其作用效果和其同系物BSPP类似[1][2][3][4]

CGP-7930
识别信息
  • 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol
CAS号57717-80-3  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C19H32O2
摩尔质量292.46 g·mol−1
3D模型(JSmol英语JSmol
  • CC(C)(C)c1cc(CC(C)(C)CO)cc(C(C)(C)C)c1O
  • InChI=1S/C19H32O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,20-21H,11-12H2,1-8H3 ☒N
  • Key:XLWJPQQFJNGUPA-UHFFFAOYSA-N ☒N

参考文献

  1. ^ Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, et al. Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. Molecular Pharmacology. November 2001, 60 (5): 963–71. PMID 11641424. 
  2. ^ Binet V, Brajon C, Le Corre L, Acher F, Pin JP, Prézeau L. The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor. The Journal of Biological Chemistry. July 2004, 279 (28): 29085–91. PMID 15126507. doi:10.1074/jbc.M400930200 . 
  3. ^ Chen Y, Menendez-Roche N, Sher E. Differential modulation by the GABAB receptor allosteric potentiator 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area. The Journal of Pharmacology and Experimental Therapeutics. June 2006, 317 (3): 1170–7. PMID 16507713. doi:10.1124/jpet.105.099176. 
  4. ^ Adams CL, Lawrence AJ. CGP7930: a positive allosteric modulator of the GABAB receptor. CNS Drug Reviews: 308–16. PMC 6494120 . PMID 17894647. doi:10.1111/j.1527-3458.2007.00021.x. 

外部链接