ERG5固醇-22-去饱和酶(英語:Sterol 22-desaturase)是真菌釀酒酵母Saccharomyces cerevisiae)基因组中的一个涉及麦角固醇生物合成细胞色素P450,其CYP编号为CYP61A1[1],是釀酒酵母三种细胞色素P450基因之一,另外两种是CYP51F1CYP56A1[2]。ERG5可催化类固醇C17侧链上C22-C23位置脱氢形成双键,如麦角固醇生物合成中的5-脱氢表甾醇(也称为“麦角三烯醇”)转化为麦角四烯醇,之后麦角四烯醇的C24双键会被酶ERG4加氢还原为麦角固醇[3]

Sterol 22-desaturase
标识
生物 Saccharomyces cerevisiae S288c
符号 ERG5
可选符号 CYP61A1
Entrez 855029
RefSeq (mRNA) NM_001182511.1
RefSeq (蛋白质) NP_013728.1
UniProt P54781
其他数据
EC number 1.14.19.41
染色体 XIII: 0.3 - 0.3 Mb

参考文献

  1. ^ Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. Global analysis of protein expression in yeast. Nature. October 2003, 425 (6959): 737–41. Bibcode:2003Natur.425..737G. PMID 14562106. doi:10.1038/nature02046. 
  2. ^ Nelson DR. Cytochrome P450 diversity in the tree of life. Biochimica et Biophysica Acta. Proteins and Proteomics. January 2018, 1866 (1): 141–154. PMC 5681887 . PMID 28502748. doi:10.1016/j.bbapap.2017.05.003. 
  3. ^ Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE. Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents. The Journal of Biological Chemistry. April 1997, 272 (15): 9986–8. PMID 9092539. doi:10.1074/JBC.272.15.9986.