LY-255582
化合物
LY-255582是一种含氮有机化合物,化学式为C22H35NO2,属于苯基哌啶类化合物,可作为阿片类受体的非选择性受体拮抗剂[1],在肥胖实验大鼠中具有减肥作用[2]。
LY-255582 | |
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IUPAC名 3-{(3R,4R)-1-[(3S)-3-Cyclohexyl-3-hydroxypropyl]-3,4-dimethylpiperidin-4-yl}phenol | |
识别 | |
CAS号 | 119193-09-8 |
PubChem | 9906198 |
ChemSpider | 8081850 |
SMILES |
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InChI |
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InChIKey | LVVHEFJXPXAUDD-BULFRSBZBD |
性质 | |
化学式 | C22H35NO2 |
摩尔质量 | 345.52 g·mol−1 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
参考文献
- ^ Dhaher R, et al. Effects of naltrexone and LY255582 on ethanol maintenance, seeking, and relapse responding by alcohol-preferring (P) rats.. Alcohol (Fayetteville, N.Y.). Feb 2012, 46 (1): 17–27. PMC 4581853 . PMID 21962974. doi:10.1016/j.alcohol.2011.08.011.
- ^ Shaw WN, et al. The effect of the opioid antagonist LY255582 on body weight of the obese Zucker rat.. International Journal of Obesity. Jun 1991, 15 (6): 387–95. PMID 1653188.