RTI-160(化学名:苯甲酰芽子碱二甲酰胺,英語:benzoylecgonine dimethylamide)是一种含氮有机化合物,分子式C18H24N2O3,带有一个莨菪烷结构,可作为多巴胺再攝取抑制劑[1][2]

RTI-160
识别信息
  • [(2R,3S)-2-(Dimethylcarbamoyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] benzoate
PubChem CID
ChemSpider
化学信息
化学式C18H24N2O3
摩尔质量316.40 g·mol−1
3D模型(JSmol英语JSmol
  • CN1C2CCC1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)N(C)C
  • InChI=1S/C18H24N2O3/c1-19(2)17(21)16-14-10-9-13(20(14)3)11-15(16)23-18(22)12-7-5-4-6-8-12/h4-8,13-16H,9-11H2,1-3H3/t13?,14?,15-,16+/m0/s1
  • Key:KCJKRDUKFUVPDP-SSHXOBKSSA-N

参考文献

  1. ^ Carroll FI, Kotian P, Dehghani A, Gray JL, Kuzemko MA, Parham KA, et al. Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter. Journal of Medicinal Chemistry. January 1995, 38 (2): 379–388. PMID 7830281. doi:10.1021/jm00002a020. 
  2. ^ Paula S, Tabet MR, Farr CD, Norman AB, Ball WJ. Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody. Journal of Medicinal Chemistry. January 2004, 47 (1): 133–142. PMID 14695827. doi:10.1021/jm030351z. 

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