促甲状腺激素β亚基
位於1號人類染色體的基因
（重定向自TSHB）
促甲状腺激素β亚基（英語：Thyroid stimulating hormone, beta，简称TSHB）是一个由人类基因TSHB 编码的蛋白质[1][2]。
| Thyroid stimulating hormone, beta 促甲状腺激素β亚基 | |||
|---|---|---|---|
| 标识 | |||
| 代号 | TSHB; TSH-B; TSH-BETA | ||
| 扩展标识 | 遗传学：188540 鼠基因：98848 同源基因：463 GeneCards: TSHB Gene | ||
| 直系同源体 | |||
| 物种 | 人类 | 小鼠 | |
| Entrez | 7252 | 22094 | |
| Ensembl | ENSG00000134200 | ENSMUSG00000027857 | |
| UniProt | P01222 | P12656 | |
| mRNA序列 | NM_000549 | NM_001165939 | |
| 蛋白序列 | NP_000540 | NP_001159411 | |
| 基因位置 |
Chr 1: 115.57 – 115.58 Mb |
Chr 3: 102.78 – 102.78 Mb | |
| PubMed查询 | [1] | [2] | |
功能
另见
参考文献
- ^ Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD. Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species. J. Biol. Chem. September 1988, 263 (25): 12538–42 [2014-03-29]. PMID 2457586. （原始内容存档于2020-04-25）.
- ^ Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K. The structure of the human thyrotropin beta-subunit gene. Gene. December 1988, 73 (2): 489–97. PMID 3243440. doi:10.1016/0378-1119(88)90513-6.
- ^ Entrez Gene: TSHB. （原始内容存档于2010-04-12）.
延伸阅读
- Bonomi M, Proverbio MC, Weber G; et al. Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene.. J. Clin. Endocrinol. Metab. 2001, 86 (4): 1600–4. PMID 11297590. doi:10.1210/jc.86.4.1600.
- Vuissoz JM, Deladoëy J, Buyukgebiz A; et al. New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism.. J. Clin. Endocrinol. Metab. 2001, 86 (9): 4468–71. PMID 11549695. doi:10.1210/jc.86.9.4468.
- Karges B, LeHeup B, Schoenle E; et al. Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe.. Horm. Res. 2004, 62 (3): 149–55. PMID 15297803. doi:10.1159/000080071.
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- Pierce JG. Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones.. Endocrinology. 1971, 89 (6): 1331–44. PMID 5002675. doi:10.1210/endo-89-6-1331.
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- Loinder K, Söderström M. An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene. J. Steroid Biochem. Mol. Biol. 2005, 97 (4): 322–7. PMID 16216492. doi:10.1016/j.jsbmb.2005.06.031.
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- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Brumm H, Pfeufer A, Biebermann H; et al. Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect. J. Clin. Endocrinol. Metab. 2002, 87 (10): 4811–6. PMID 12364478. doi:10.1210/jc.2002-020297.
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