Template:PBB/6737

三分模體包含蛋白質21（TRIM21）
Tripartite motif containing 21
三分模體包含蛋白質21（TRIM21）; Tripartite motif containing 21
	兩分子TRIM21的晶體結構。其中，兩分子TRIM21C端的PRYSPRY結構域分別位於左上方和左下方。它們均與位於中央的IGHG1同質二聚體C區域結合。其中，多肽鏈的C端被渲染爲紅色，N端被渲染爲藍色
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2IWG
标识
代号	TRIM21; RNF81; RO52; Ro/SSA; SSA; SSA1
扩展标识	遗传学：109092 鼠基因：106657 同源基因：2365 GeneCards: TRIM21 Gene
EC編號	6.3.2.-
基因本体论描述
分子功能	· DNA binding; · RNA binding; · ubiquitin-protein transferase activity; · protein binding; · zinc ion binding; · ligase activity; · identical protein binding;
细胞成分	· cytoplasmic mRNA processing body; · nucleus; · nucleoplasm; · cytoplasm; · cytosol; · SCF ubiquitin ligase complex; · ribonucleoprotein complex;
生物过程	· protein polyubiquitination; · protein monoubiquitination; · cell cycle; · protein ubiquitination; · cytokine-mediated signaling pathway; · protein destabilization; · negative regulation of NF-kappaB transcription factor activity; · regulation of type I interferon production; · positive regulation of type I interferon production; · negative regulation of viral transcription; · innate immune response; · positive regulation of cell cycle; · positive regulation of viral entry into host cell; · positive regulation of sequence-specific DNA binding transcription factor activity; · protein autoubiquitination; · interferon-gamma-mediated signaling pathway; · protein trimerization; · negative regulation of protein deubiquitination; · negative regulation of viral release from host cell;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	6737
Ensembl	ENSG00000132109
UniProt	P19474
mRNA序列	NM_003141
蛋白序列	NP_003132
基因位置	Chr 11:; 4.38 – 4.39 Mb
PubMed查询	[1]
	查; 论; 编;

参考资料

^ PDB 2IWG; James LC, Keeble AH, Khan Z, Rhodes DA, Trowsdale J. Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function. Proc. Natl. Acad. Sci. U.S.A. April 2007, 104 (15): 6200–5. PMC 1851072 . PMID 17400754. doi:10.1073/pnas.0609174104.

[pmid17400754-1] PDB 2IWG; James LC, Keeble AH, Khan Z, Rhodes DA, Trowsdale J. Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function. Proc. Natl. Acad. Sci. U.S.A. April 2007, 104 (15): 6200–5. PMC 1851072 . PMID 17400754. doi:10.1073/pnas.0609174104.

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