WNT974
化合物
WNT974是一种有机化合物，化学式为C23H20N6O。它可以2-氨基吡啶-5-硼酸频哪醇酯和2-碘吡嗪为原料，经多步反应制得。[1]它是一种Wnt信号抑制剂。[2][3]
| WNT974 | |
|---|---|
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| 别名 | LGK974 |
| 识别 | |
| CAS号 | 1243244-14-5 
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| SMILES |
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| 性质 | |
| 化学式 | C23H20N6O |
| 摩尔质量 | 396.44 g·mol−1 |
| 外观 | 白色固体[1] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
参考文献
- ^ 1.0 1.1 Dai Cheng; Jun Liu; Dong Han; et al. Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS Med. Chem. Lett. 2016, 7, 7, 676–680. doi:10.1021/acsmedchemlett.6b00038.
- ^ Shuying Xie; Wenbin Fu; Guangju Yu; et al. Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair. Journal of Molecular Cell Biology, 2020. 12 (1): 42-54. doi:10.1093/jmcb/mjz023.
- ^ Jun Liu; Shifeng Pan; Mindy H. Hsieh; et al. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proceedings of the National Academy of Sciences of the United States of America (2013), 110(50). doi:10.1073/pnas.1314239110.