芳基醇脱氢酶 (NADP+)

芳基醇脱氢酶 (NADP+)(英語:aryl-alcohol dehydrogenase (NADP+)EC 1.1.1.91页面存档备份,存于互联网档案馆)),是一种以NAD+NADP+受体、作用于供体CH-OH基团上的氧化还原酶。这种催化以下酶促反应

芳基醇脱氢酶 (NADP+)
识别码
EC編號 1.1.1.91
CAS号 37250-27-4
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO
芳基 + NADP+ 芳基 + NADPH + H+

芳基醇脱氢酶 (NADP+)的等电点为5.2,在pH值为6.1时活性最高。这种酶主要作用在芳基醇上,但也能作用于一些芳基醛,但不能还原芳基。现发现最适合芳基醇脱氢酶 (NADP+)的底物肉桂醛。这种酶对苯环上有甲基取代基的底物比有羟基取代基的底物具有更强的特异性。[1]芳基醇脱氢酶 (NADP+)能被对-氯汞基苯甲酸盐p-chloromercuribenzoate,pCMB)或1,10-菲罗啉抑制。[2]

参考文献

  1. ^ Andreas Muheim, Roland Waldner, Dominique Sanglard, Jakob Reiser, Hans E. Schoemaker, Matti S. A. Leisola. Purification and properties of an aryl-alcohol dehydrogenase from the white-rot fungus Phanerochaete chrysosporium. European Journal of Biochemistry. Jan 1991, 195 (2): 369–375. doi:10.1111/j.1432-1033.1991.tb15715.x. 
  2. ^ N.H. Sloane. Metablites of p-aminobenzoic acid V. Isolation and properties of p-aminobenzyl alcohol dehydrogenase. Biochimica et Biophysica Acta (BBA)-Enzymology. Nov 15, 1973, 327 (1): 11–18. doi:10.1016/0005-2744(73)90097-1. 
  • Gross GG, Zenk MH. Reduction of aromatic acids to aldehydes and alcohols in the cell-free system. 2. Purification and properties of aryl-alcohol: NADP-oxidoreductase from Neurospora crassa. Eur. J. Biochem. 1969, 8 (3): 420–425. PMID 4389864.