维基百科

视网膜母细胞瘤蛋白

在智人中發現的哺乳動物蛋白質

视网膜母细胞瘤蛋白（英語：retinoblastoma protein，常缩写为Rb、RB或RB1）又译为成视网膜细胞瘤蛋白是一种抑癌蛋白，并在几种主要的癌症发生时失活[6]。Rb的功能之一是通过抑制细胞周期进程直到细胞准备妥当来防止细胞过度生长。当细胞准备好要分裂时，Rb蛋白会被磷酸化为pRb而失去抑制活性，从而使细胞周期进行下去。

视网膜母细胞瘤蛋白
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名RB1；, pRb, RB, retinoblastoma 1, OSRC, PPP1R130, p105-Rb, pp110, Retinoblastoma protein, RB transcriptional corepressor 1, p110-RB1
外部IDOMIM：614041 MGI：97874 HomoloGene：272 GeneCards：RB1
相關疾病
膀胱癌、​lung small cell carcinoma、​familial retinoblastoma[1]
基因位置（人类）
13號染色體
染色体13號染色體[2]
13號染色體
视网膜母细胞瘤蛋白的基因位置
视网膜母细胞瘤蛋白的基因位置
基因座13q14.2起始48,303,744 bp[2]
终止48,599,436 bp[2]
RNA表达模式


查阅更多表达数据
直系同源
物種人類小鼠
Entrez

5925

19645

Ensembl

ENSG00000139687

ENSMUSG00000022105

UniProt

P06400

P13405

mRNA​序列

NM_000321

NM_009029

蛋白序列

NP_000312
NP_000312.2

NP_033055

基因位置​（UCSC）Chr 13: 48.3 – 48.6 MbChr 14: 73.42 – 73.56 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

Rb是袋状蛋白家族的一员，其特点是有一个口袋状的结构用以结合其它蛋白[7][8]。使得一些致癌变蛋白，比如高危险群人类乳突病毒所感染的细胞产生的蛋白，结合并抑制pRb，最终导致癌症。


相互作用

已知Rb蛋白与下列蛋白质有相互作用关系：

 
细胞凋亡中涉及的信号通路一览

参考文献

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视网膜母细胞瘤蛋白引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。


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