Pho4
Pho4是一种在釀酒酵母（S. cerevisiae）中发现的碱性螺旋-环-螺旋（bHLH）转录因子，在其它酵母中也有发现[2]
| Pho4 | |
|---|---|
| |
| Crystallographic structure of yeast Pho4 homodimer (cyan and green) complexed with DNA (brown).[1] | |
| 标识 | |
| 生物 | ? |
| 符号 | Pho4 |
| 可选符号 | YFR034C |
| Entrez | 850594 |
| PDB | 1a0a |
| UniProt | P07270 |
| 其他数据 | |
Pho4蛋白形成同源二聚体后进入细胞核结合DNA，其识别位点为：5'-CACGTG-3'[3]，这一序列常出现在Pho5等磷酸酶基因的啟動子区域[4]。
参考文献
- ^ PDB 1a0a; Shimizu T, Toumoto A, Ihara K, Shimizu M, Kyogoku Y, Ogawa N, Oshima Y, Hakoshima T. Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition. EMBO J. August 1997, 16 (15): 4689–97. PMC 1170095
. PMID 9303313. doi:10.1093/emboj/16.15.4689.
- ^ Berben G, Legrain M, Gilliquet V, Hilger F. The yeast regulatory gene PHO4 encodes a helix-loop-helix motif. Yeast. 1990, 6 (5): 451–4. PMID 2220078. doi:10.1002/yea.320060510.
- ^ Shao D, Creasy CL, Bergman LW. A cysteine residue in helixII of the bHLH domain is essential for homodimerization of the yeast transcription factor Pho4p. Nucleic Acids Res. February 1998, 26 (3): 710–4. PMC 147311 . PMID 9443961. doi:10.1093/nar/26.3.710.
- ^ Ogawa N, Oshima Y. Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae. Mol. Cell. Biol. May 1990, 10 (5): 2224–36. PMC 360570 . PMID 2183025. doi:10.1128/mcb.10.5.2224.
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