丙咪嗪

丙咪嗪
临床资料
商品名（英语：Drug nomenclature）	Tofranil, Tofranil-PM, others
其他名称	Melipramine; G-22355
AHFS/Drugs.com	Monograph
MedlinePlus	a682389
核准状况	美 DailyMed: Imipramine;
怀孕分级	澳: C ; ;
给药途径	By mouth, intramuscular injection
ATC码	N06AA02 (WHO) ;
法律规范状态
法律规范	澳：限医生处方（S4）; 加：处方药（℞-only）; 英：处方药（℞-only） (POM); 美：处方药（℞-only）;
药物动力学数据
生物利用度	94–96%
血浆蛋白结合率	86%
药物代谢	Liver (CYP1A2, CYP2C19, CYP2D6)
代谢产物	Desipramine
生物半衰期	20 hours
排泄途径	Kidney (80%), fecal (20%)
识别信息
	IUPAC命名法 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine; ;
CAS号	50-49-7
PubChem CID	3696;
IUPHAR/BPS	357;
DrugBank	DB00458 ;
ChemSpider	3568 ;
UNII	OGG85SX4E4;
KEGG	D08070 ; as HCl: D00815 ;
ChEBI	CHEBI:47499 ;
ChEMBL	ChEMBL11 ;
PDB配体ID	IXX (PDBe, RCSB PDB);
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID1043881 ;
ECHA InfoCard	100.000.039
化学信息
化学式	C19H24N2
摩尔质量	280.42 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CN(C)CCCN1c2ccccc2CCc2ccccc21;
	InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 ; Key:BCGWQEUPMDMJNV-UHFFFAOYSA-N ;

丙咪嗪是一种口服三环类抗抑郁药，主要用于治疗抑郁。它还可以治疗焦虑和恐慌症。^[5]^[6]^[7]

丙咪嗪的常见副作用有口干、昏睡、头晕、低血压、心跳过速、尿潴留。丙咪嗪过量可能会导致死亡。

丙咪嗪于1951年被发现，并于1957年投入临床使用。

参考文献

^ Imipramine Use During Pregnancy. Drugs.com. 28 August 2019 [7 February 2020]. （原始内容存档于2020-02-07）.
^ Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, et al. Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: increasing the power of bioavailability tests. Journal of Pharmacokinetics and Biopharmaceutics. June 1979, 7 (3): 233–248. PMID 480146. S2CID 23232584. doi:10.1007/BF01060015.
^ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Product Information Tolerade (imipramine hydrochloride). TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013 [16 October 2013]. （原始内容存档于10 December 2019）.
^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. （原始内容存档于2023-08-03）（巴西葡萄牙语）.
^ Robert R, Blakeney PE, Villarreal C, Rosenberg L, Meyer WJ. Imipramine treatment in pediatric burn patients with symptoms of acute stress disorder: a pilot study. Journal of the American Academy of Child and Adolescent Psychiatry. July 1999, 38 (7): 873–882. PMID 10405506. doi:10.1097/00004583-199907000-00018.
^ Tcheung WJ, Robert R, Rosenberg L, Rosenberg M, Villarreal C, Thomas C, et al. Early treatment of acute stress disorder in children with major burn injury. Pediatric Critical Care Medicine. November 2005, 6 (6): 676–681. PMID 16276335. S2CID 43261789. doi:10.1097/01.pcc.0000165562.04157.da.
^ Robert R, Tcheung WJ, Rosenberg L, Rosenberg M, Mitchell C, Villarreal C, et al. Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: a randomized, double-blind study. Burns. November 2008, 34 (7): 919–928. PMID 18675519. doi:10.1016/j.burns.2008.04.009.

[Drugs.com_pregnancy-1] Imipramine Use During Pregnancy. Drugs.com. 28 August 2019 [7 February 2020]. （原始内容存档于2020-02-07）.

[Pharm-2] Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, et al. Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: increasing the power of bioavailability tests. Journal of Pharmacokinetics and Biopharmaceutics. June 1979, 7 (3): 233–248. PMID 480146. S2CID 23232584. doi:10.1007/BF01060015.

[Tolerade-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Product Information Tolerade (imipramine hydrochloride). TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013 [16 October 2013]. （原始内容存档于10 December 2019）.

[4] Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. （原始内容存档于2023-08-03）（巴西葡萄牙语）.

[pmid10405506-5] Robert R, Blakeney PE, Villarreal C, Rosenberg L, Meyer WJ. Imipramine treatment in pediatric burn patients with symptoms of acute stress disorder: a pilot study. Journal of the American Academy of Child and Adolescent Psychiatry. July 1999, 38 (7): 873–882. PMID 10405506. doi:10.1097/00004583-199907000-00018.

[pmid16276335-6] Tcheung WJ, Robert R, Rosenberg L, Rosenberg M, Villarreal C, Thomas C, et al. Early treatment of acute stress disorder in children with major burn injury. Pediatric Critical Care Medicine. November 2005, 6 (6): 676–681. PMID 16276335. S2CID 43261789. doi:10.1097/01.pcc.0000165562.04157.da.

[pmid18675519-7] Robert R, Tcheung WJ, Rosenberg L, Rosenberg M, Mitchell C, Villarreal C, et al. Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: a randomized, double-blind study. Burns. November 2008, 34 (7): 919–928. PMID 18675519. doi:10.1016/j.burns.2008.04.009.

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