Sp8转录因子

Sp8转录因子
识别号
别名	SP8；, BTD, Sp8 transcription factor
外部ID	OMIM：608306 MGI：2443471 HomoloGene：18548 GeneCards：SP8
基因位置（人类）
染色体	7号染色体
终止	20,786,886 bp
基因位置（小鼠）
染色体	小鼠12号染色体
终止	118,816,311 bp
基因本体
分子功能	• DNA结合; • 金属离子结合; • nucleic acid binding; • DNA-binding transcription factor activity, RNA polymerase II-specific;
细胞组分	• 细胞核;
生物学过程	• proximal/distal pattern formation; • regulation of transcription, DNA-templated; • dorsal/ventral pattern formation; • embryonic limb morphogenesis; • transcription, DNA-templated; • regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
直系同源
	221833
	320145
	ENSG00000164651
	ENSMUSG00000048562
	Q8IXZ3
	Q8BMJ8
	NM_182700; NM_198956
	NM_177082; NM_001379379; NM_001379380
	NP_874359; NP_945194
	NP_796056; NP_001366308; NP_001366309
	维基数据
查看/编辑人类	查看/编辑小鼠

Sp8转录因子又称为特异性蛋白8（specificity protein 8、SP-8）或Btd转录因子^[5]是由SP8基因编码的人类蛋白质^[6]^[7]，位于人类的7号染色体中。Sp8是Sp/KLF家族的转录因子。

功能

Sp8在肢体生长早起扮演了协调的作用。^[5]在小鼠实验中，若小鼠缺失Sp8基因会导致严重的脑外畸形（英语：Exencephaly）。^[8]

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000164651 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000048562 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A. mBtd is required to maintain signaling during murine limb development (PDF). Genes & Development. November 2003, 17 (21): 2630–5 [2024-01-28]. PMC 280612  . PMID 14597661. doi:10.1101/gad.274103. （原始内容存档 (PDF)于2017-09-22）.
^ Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ. Sp8 is crucial for limb outgrowth and neuropore closure. Proceedings of the National Academy of Sciences of the United States of America. October 2003, 100 (21): 12195–200. PMC 218735  . PMID 14526104. doi:10.1073/pnas.2134310100  .
^ Entrez Gene: Sp8 transcription factor.
^ Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K. The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Neuron. February 2006, 49 (4): 503–16. PMID 16476661. S2CID 17734218. doi:10.1016/j.neuron.2006.01.018  .

延伸阅读

Lee MT, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC, Chiu NY, Chuo LJ, Chen CY, Tan HK, Lane HY, Chang TJ, Lin CH, Jou SH, Hou YM, Feng J, Lai TJ, Tung CL, Chen TJ, Chang CJ, Lung FW, Chen CK, Shiah IS, Liu CY, Teng PR, Chen KH, Shen LJ, Cheng CS, Chang TP, Li CF, Chou CH, Chen CY, Wang KH, Fann CS, Wu JY, Chen YT, Cheng AT. Genome-wide association study of bipolar I disorder in the Han Chinese population. Molecular Psychiatry. May 2011, 16 (5): 548–56. PMID 20386566. S2CID 41746496. doi:10.1038/mp.2010.43. 温哥华格式错误 (帮助)
Milona MA, Gough JE, Edgar AJ. Genomic structure and cloning of two transcript isoforms of human Sp8. BMC Genomics. November 2004, 5: 86. PMC 534095  . PMID 15533246. doi:10.1186/1471-2164-5-86  .
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. PLOS ONE. July 2010, 5 (7): e11493. Bibcode:2010PLoSO...511493J. PMC 2901336  . PMID 20634891. doi:10.1371/journal.pone.0011493  . 温哥华格式错误 (帮助)
Barber MJ, Mangravite LM, Hyde CL, Chasman DI, Smith JD, McCarty CA, Li X, Wilke RA, Rieder MJ, Williams PT, Ridker PM, Chatterjee A, Rotter JI, Nickerson DA, Stephens M, Krauss RM. Genome-wide association of lipid-lowering response to statins in combined study populations. PLOS ONE. March 2010, 5 (3): e9763. Bibcode:2010PLoSO...5.9763B. PMC 2842298  . PMID 20339536. doi:10.1371/journal.pone.0009763  .
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome Research. January 2006, 16 (1): 55–65. PMC 1356129  . PMID 16344560. doi:10.1101/gr.4039406.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y. An atlas of combinatorial transcriptional regulation in mouse and man. Cell. March 2010, 140 (5): 744–52. PMC 2836267  . PMID 20211142. doi:10.1016/j.cell.2010.01.044.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000164651 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000048562 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14597661-5] 5.0 ^5.1 Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A. mBtd is required to maintain signaling during murine limb development (PDF). Genes & Development. November 2003, 17 (21): 2630–5 [2024-01-28]. PMC 280612  . PMID 14597661. doi:10.1101/gad.274103. （原始内容存档 (PDF)于2017-09-22）.

[pmid14526104-6] Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ. Sp8 is crucial for limb outgrowth and neuropore closure. Proceedings of the National Academy of Sciences of the United States of America. October 2003, 100 (21): 12195–200. PMC 218735  . PMID 14526104. doi:10.1073/pnas.2134310100  .

[entrez-7] Entrez Gene: Sp8 transcription factor.

[pmid16476661-8] Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K. The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Neuron. February 2006, 49 (4): 503–16. PMID 16476661. S2CID 17734218. doi:10.1016/j.neuron.2006.01.018  .

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