前维生素D3
化合物
维生素D3原（又称：前维生素D3，英语：Previtamin D3）是胆钙化醇（维生素D3）合成的中间产物，由皮肤表皮中的7-脱氢胆固醇在紫外线（主要是295nm - 300nm 的UV-B）照射下开环生成[1][2][3][4]。
| Previtamin D3 | |
|---|---|
| |
| IUPAC名 Previtamin D3 | |
| 识别 | |
| CAS号 | 1173-13-3  17592-07-3
|
| PubChem | 86590 6178113（(E)-en） 25245851（(1S)-1-ol, (Z)-en, (2R)-2-yl） 11485943（(1S)-1-ol, (E)-en, (1R,7aR)-7a-meth,-1-hept, (2R)-2-yl） 11199982（(1S)-1-ol, (Z)-en, (1R,7aR)-7a-meth,-1-hept, (2R)-2-yl） |
| ChemSpider | 78098, 4832524 (E)-en, 9660762 (1S)-1-ol, (E)-en, (1R,7aR)-7a-meth,-1-hept, (2R)-2-yl, 9375051 (1S)-1-ol, (Z)-en, (1R,7aR)-7a-meth,-1-hept, (2R)-2-yl |
| SMILES |
|
| EINECS | 241-561-3 |
| MeSH | Previtamin+D(3) |
| 性质 | |
| 化学式 | C27H44O |
| 摩尔质量 | 384.64 g·mol−1 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
参考文献
- ^ MacLaughlin JA, Anderson RR, Holick MF. Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. Science. May 1982, 216 (4549): 1001–3. Bibcode:1982Sci...216.1001M. PMID 6281884. doi:10.1126/science.6281884.
- ^ Webb AR. Who, what, where and when-influences on cutaneous vitamin D synthesis. Progress in Biophysics and Molecular Biology. September 2006, 92 (1): 17–25. PMID 16766240. doi:10.1016/j.pbiomolbio.2006.02.004.
- ^ Pope SJ, Holick MF, Mackin S, Godar DE. Action spectrum conversion factors that change erythemally weighted to previtamin D3-weighted UV doses. Photochemistry and Photobiology. 2008, 84 (5): 1277–83. PMID 18513232. doi:10.1111/j.1751-1097.2008.00373.x.
- ^ Sayre RM, Dowdy JC. Darkness at noon: sunscreens and vitamin D3. Photochemistry and Photobiology. 2007, 83 (2): 459–63. PMID 17115796. doi:10.1562/2006-06-29-RC-956.