反老药(Senolytic)是一类受到基础科学研究以确定其是否能选择性地杀死衰老细胞并增进人体健康的小分子物质;[1]这类研究的目标是找出或开发能延缓、阻止、纾解甚至逆转老化相关疾病的药物。[2][3]与此类研究相关的一个概念是“冻龄”(senostatic),其意为抑制老化。

研究

目前对返老药的研究处于初步阶段,其中一些已经进入人体试验阶段的早期。[4]目前多数潜在的返老药,其原本的目的是用作抗癌药物,像是用于化疗的药物达沙替尼以及实验性的小分子药物那维托克(Navitoclax,ABT-263)等是其中的例子。[5][6]

潜在的反老药

临床试验

尽管目前只有少数的返老药进入临床测试的阶段,但一项人体初步临床试验显示,达沙替尼槲皮素的混合物在患有糖尿病肾脏病变的人类患者中,确会降低部分组织当中衰老细胞的数量。[10]

参见

参考资料

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