4T1细胞
4T1是一种乳癌细胞系，来源于BALB/c小鼠的癌变乳腺组织，4T1细胞带有上皮细胞的性质，并且能耐受肿瘤药物6-硫鸟嘌呤[1]。4T1细胞是一种雌激素受体（ER）、孕酮受体（PR）和人表皮生长因子受体-2（Her⁃2）均为阴性的乳腺癌细胞[2]。在科研中，4T1细胞常用作乳腺癌远端转移的研究模型[3]及临床药物筛选使用最多的乳腺癌模型[4][5]，这些细胞对小鼠肺组织有着很高的侵袭性[6]。
参考文献
- ^ Pulaski, BA; Ostrand-Rosenberg, S. Mouse 4T1 breast tumor model. Current Protocols in Immunology. May 2001, 20 (20). PMID 18432775. doi:10.1002/0471142735.im2002s39.
- ^ 黄迪; 黄宇; 翁杰锋; 黄子圣; 麦振豪; 赵俐; 古维立. Reversine對小鼠乳腺癌4T1細胞增殖和凋亡的調控及相關作用機制的研究. 实用医学杂志. 2018, 34 (14): 2324-2328 [2019-11-19]. doi:10.3969/j.issn.1006-5725.2018.14.011.[失效链接]
- ^ Shengyu, Yang; et al. Mouse Models for Tumor Metastasis. Methods in Molecular Biology. 2012, 928: 221–228. PMC 3674868
. doi:10.1007/978-1-62703-008-3_17.
- ^ Tao, K; Fang, M; Alroy, J; Sahagian, GG. Imagable 4T1 model for the study of late stage breast cancer.. BMC cancer. 2008-08-09, 8: 228 [2019-11-19]. PMID 18691423. doi:10.1186/1471-2407-8-228.
- ^ Liao, D; Luo, Y; Markowitz, D; Xiang, R; Reisfeld, RA. Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model.. PloS one. 2009-11-23, 4 (11): e7965 [2019-11-19]. PMID 19956757. doi:10.1371/journal.pone.0007965.
- ^ Disch, Bryan; et al. Development and Characterization of a Preclinical Model of Breast Cancer Lung Micrometastatic to Macrometastatic Progression. PLoS ONE. 30 May 2014, 9 (5) [2020-12-07]. PMC 4039511 . doi:10.1371/journal.pone.0098624. （原始内容存档于2020-09-18）.
