M34细胞

M34是一种人类皮肤黑色素瘤细胞系^[1]，特点是其β2-微球蛋白基因发生了TTCT四碱基删失形成终止密码子造成了无义突变^[2]，常用于生物医学研究^[3]。

参考资料

^ Jiang, X; Zhou, J; Yuen, NK; Corless, CL; Heinrich, MC; Fletcher, JA; Demetri, GD; Widlund, HR; Fisher, DE; Hodi, FS. Imatinib targeting of KIT-mutant oncoprotein in melanoma.. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008-12-01, 14 (23): 7726–32. PMID 19047099. doi:10.1158/1078-0432.CCR-08-1144.
^ Fernández, MA; Ruiz-Cabello, F; Oliva, MR; Cabrera, T; Jimenez, P; López Nevot, MA; Garrido, F. Beta2-microglobulin gene mutation is not a common mechanism of HLA class I total loss in human tumors.. International journal of clinical & laboratory research. 2000, 30 (2): 87–92. PMID 11043502. doi:10.1007/BF02874164.
^ Kucukkaraduman, B; Turk, C; Fallacara, AL; Isbilen, M; Senses, KM; Ayyildiz, ZO; Akbar, MW; Lotem, M; Botta, M; Gure, AO. Predictive Gene Signature for Pyrazolopyrimidine Derivative c-Src Inhibitor 10a Sensitivity in Melanoma Cells.. ACS medicinal chemistry letters. 2020-05-14, 11 (5): 928–932. PMID 32435407. doi:10.1021/acsmedchemlett.9b00679.

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