PER2

PER2
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3GDI、4CT0、4U8H
识别号
别名	PER2；, FASPS, FASPS1, period circadian clock 2, period circadian regulator 2
外部ID	OMIM：603426 MGI：1195265 HomoloGene：7885 GeneCards：PER2
相关疾病
	advanced sleep phase syndrome
基因位置（人类）
染色体	2号染色体
终止	238,290,102 bp
基因位置（小鼠）
染色体	小鼠1号染色体
终止	91,387,046 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• 转录共激活因子活性; • transcription cis-regulatory region binding; • 血浆蛋白结合; • transcription corepressor binding; • 转录因子结合;
细胞组分	• 核仁; • 细胞质的核周区域; • 细胞核; • 细胞质;
生物学过程	• histone H3 deacetylation; • 糖异生; • regulation of transcription, DNA-templated; • regulation of insulin secretion; • rhythmic process; • negative regulation of fat cell proliferation; • negative regulation of circadian rhythm; • negative regulation of transcription by RNA polymerase II; • circadian regulation of gene expression; • transcription, DNA-templated; • 脂肪酸代谢; • regulation of cell cycle; • negative regulation of protein ubiquitination; • circadian regulation of translation; • response to ischemia; • regulation of vasoconstriction; • glycogen biosynthetic process; • negative regulation of transcription regulatory region DNA binding; • regulation of circadian rhythm; • 昼夜节律; • white fat cell differentiation; • regulation of glutamate uptake involved in transmission of nerve impulse; • lactate biosynthetic process; • negative regulation of transcription, DNA-templated; • regulation of neurogenesis; • positive regulation of nucleic acid-templated transcription; • response to light stimulus; • entrainment of circadian clock by photoperiod; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
直系同源
	8864
	18627
	ENSG00000132326
	ENSMUSG00000055866
	O15055
	O54943
	NM_003894; NM_022817
	NM_011066
	NP_073728
	NP_035196
	维基数据
查看/编辑人类	查看/编辑小鼠

PER2是由人类基因per2 编码的蛋白质，与昼夜节律有关^[6]^[7]，是黑腹果蝇 Period 基因在哺乳动物基因组中的同源物^[8]。

参考文献

^ 與PER2相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000132326 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000055866 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–9. PMID 9427249. S2CID 10059149. doi:10.1016/S0896-6273(00)80417-1  .
^ Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptácek LJ. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell. Jan 2007, 128 (1): 59–70. PMC 1828903  . PMID 17218255. doi:10.1016/j.cell.2006.11.043.
^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–1269. PMID 9427249. S2CID 10059149. doi:10.1016/s0896-6273(00)80417-1  .

外部链接

医学主题词表（MeSH）：PER2+protein,+human
PDB中UniProt可用的所有结构信息之概述：O15055 (Human Period circadian protein homolog 2) 在PDBe-KB（英语：PDBe-KB）。
PDB中UniProt可用的所有结构信息之概述：O54943 (Mouse Period circadian protein homolog 2) 在PDBe-KB（英语：PDBe-KB）。

[1] 與PER2相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000132326 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000055866 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9427249-6] Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–9. PMID 9427249. S2CID 10059149. doi:10.1016/S0896-6273(00)80417-1  .

[pmid17218255-7] Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptácek LJ. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell. Jan 2007, 128 (1): 59–70. PMC 1828903  . PMID 17218255. doi:10.1016/j.cell.2006.11.043.

[8] Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–1269. PMID 9427249. S2CID 10059149. doi:10.1016/s0896-6273(00)80417-1  .

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