丙型肝炎病毒非結構蛋白3

非結構蛋白3(英語:Nonstructural protein 3,簡稱NS3),也稱為p-70,是一種病毒非結構蛋白,是丙型肝炎病毒多蛋白的70 kDa裂解產物。它充當絲氨酸蛋白酶[1][2]該蛋白的C端三分之二也充當解旋酶核苷三磷酸酶[3]NS3的前(N端)180個氨基酸具有作為NS2蛋白的輔助因子結構域的額外作用。[4]

丙型肝炎病毒基因組

參見

參考資料

  1. ^ Hijikata, M.; et al. Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Proc. Natl. Acad. Sci. USA. 1993, 90 (22): 10773–10777. Bibcode:1993PNAS...9010773H. PMC 47860 . PMID 7504283. doi:10.1073/pnas.90.22.10773 . 
  2. ^ Raney, Kevin D.; Sharma, Suresh D.; Moustafa, Ibrahim M.; Cameron, Craig E. Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target. Journal of Biological Chemistry. 2010, 285 (30): 22725–22731. PMC 2906261 . PMID 20457607. doi:10.1074/jbc.R110.125294 . 
  3. ^ Stimulation of Hepatitis C Virus (HCV) Nonstructural Protein 3 (NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase頁面存檔備份,存於網際網路檔案館) / J. Virol. July 2005 vol. 79 no. 14 8687-8697
  4. ^ Schregel, V; Jacobi, S; Penin, F; Tautz, N. Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3. Proc Natl Acad Sci U S A. 2009, 106 (13): 5342–7. Bibcode:2009PNAS..106.5342S. PMC 2663979 . PMID 19282477. doi:10.1073/pnas.0810950106 . 
  5. ^ NS3/4A Protease Inhibitors - DrugBank. [2024-03-03]. (原始內容存檔於2017-11-07). 

外部連結