1-萘基縮水甘油醚
化合物
1-萘基縮水甘油醚是一種有機化合物，化學式為C13H12O2。它可由環氧氯丙烷和1-萘酚在氫氧化鉀存在下反應得到。[3]它和疊氮化鈉在四丁基溴化銨催化下，於乙醇水溶液中反應，可以得到1-疊氮基-3-(1-萘氧基)-2-丙醇。[4]它和1-(2-甲氧基苯基)哌嗪在乙醇中回流反應，可以得到萘哌地爾。[5]
| 1-萘基縮水甘油醚 | |
|---|---|
| |
| 識別 | |
| CAS號 | 2461-42-9 
|
| 性質 | |
| 化學式 | C13H12O2 |
| 摩爾質量 | 200.23 g·mol−1 |
| 外觀 | 接近無色的油狀液體[1]或淺黃色油狀液體[2] |
| 沸點 | 203—203.5 °C（476.1—476.6 K）（15 mmHg）[1] |
| 溶解性（水） | 微溶於氯仿和乙酸乙酯[2] |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
參考文獻
- ^ 1.0 1.1 Ernest Robert Marle. XXXVIII.—The aryl ethers of glycide, glycerol, and glycerol-α-monochlorohydrin. J. Chem. Soc., Trans. 1912, 101 (0): 305–317 [2023-04-08]. ISSN 0368-1645. doi:10.1039/CT9120100305 （英語）.
- ^ 2.0 2.1 N378400 a-Naphthyl Glycidyl Ether, 90%. Toronto Research Chemicals. [2023-04-08]. （原始內容存檔於2023-04-10）.
- ^ Ali Gharib, Manouchehr Jahangir, Mina Roshani, Nader Noroozi Pesyan, J. (Hans) W. Scheeren, Sara Mohadesazadeh, Shirin Lagzian. Synthesis of ( S )-(-)-Propranolol by Using Cs 2.5 H 0.5 PW 12 O 40 Nanocatalyst as Green, Eco-Friendly, Reusable, and Recyclable Catalyst. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry. 2015-03-04, 45 (3): 350–355 [2023-04-08]. ISSN 1553-3174. doi:10.1080/15533174.2013.832323 （英語）.
- ^ Perumal Sarojini, Malaichamy Jeyachandran, Dharmarajan Sriram, Palraj Ranganathan, S Gandhimathi. Facile microwave-assisted synthesis and antitubercular evaluation of novel aziridine derivatives. Journal of Molecular Structure. 2021-06, 1233: 130038 [2023-04-08]. doi:10.1016/j.molstruc.2021.130038 （英語）.
- ^ Kanno, Takeshi; Tanaka, Akito; Shimizu, Tadashi; Nakano, Takashi; Nishizaki, Tomoyuki. Preparation of naftopidil analogs as novel anticancer agent. 2015. US20150353473.