涎腺玻璃樣變透明細胞癌
涎腺玻璃樣變透明細胞癌（Hyalinizing clear cell carcinoma，HCCC）是一種罕見的惡性唾液腺腫瘤，預後良好，通常見於舌頭或上顎。[1]
| 涎腺玻璃樣變透明細胞癌 | |
|---|---|
 | |
| 顯微照片 | |
| 分類和外部資源 | |
| 醫學專科 | 腫瘤學、耳鼻喉科學 |
症狀
診斷
HCCC通過組織檢查（例如活體組織切片）來診斷。
病理
HCCC由具有豐富透明細胞質的細胞組成，呈索狀、小梁狀或簇狀排列於透明基質中。[3]核多形性通常很小，少見有絲分裂。[2]
由於腫瘤細胞的糖原含量，其在顯微鏡下外觀清晰，可被PAS染色。S100和平滑肌肌動蛋白（SMA）的免疫染色通常為陰性，而細胞角蛋白和上皮膜抗原（EMA）則為陽性。
預後
HCCC通常預後良好。[5]
參考文獻
- ^ Kauzman, A.; Tabet, JC.; Stiharu, TI. Hyalinizing clear cell carcinoma: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Jul 2011, 112 (1): e26–34. PMID 21669357. doi:10.1016/j.tripleo.2011.02.041.
- ^ 2.0 2.1 Milchgrub, S.; Gnepp, DR.; Vuitch, F.; Delgado, R.; Albores-Saavedra, J. Hyalinizing clear cell carcinoma of salivary gland. Am J Surg Pathol. Jan 1994, 18 (1): 74–82. PMID 7506496. doi:10.1097/00000478-199401000-00007.
- ^ O'Sullivan-Mejia, ED.; Massey, HD.; Faquin, WC.; Powers, CN. Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. Head Neck Pathol. Sep 2009, 3 (3): 179–85. PMC 2811632
. PMID 20596970. doi:10.1007/s12105-009-0124-3.
- ^ Antonescu, CR.; Katabi, N.; Zhang, L.; Sung, YS.; Seethala, RR.; Jordan, RC.; Perez-Ordoñez, B.; Have, C.; et al. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer. Jul 2011, 50 (7): 559–70. PMID 21484932. doi:10.1002/gcc.20881.
- ^ Masilamani, S.; Rao, S.; Chirakkal, P.; Kumar, AR. Hyalinizing clear cell carcinoma of the base of tongue: a distinct and rare entity. Indian J Pathol Microbiol. 2011, 54 (1): 167–9. PMID 21393908. doi:10.4103/0377-4929.77393.
