Cyp11b3大鼠的一個編碼CYP450基因,主要在大鼠新生兒腎上腺表達,在成年大鼠的其它器官也有少量表達,主要作用是催化11-去氧皮質酮(DOC)生成18-羥基-11-去氧皮質酮(18-OH-DOC)[1] CYP11B3和CYP11B1英語Steroid 11-beta-hydroxylaseCYP11B2英語Aldosterone synthase基因都位於大鼠染色體7q34上。

cytochrome P450, family 11, subfamily b, polypeptide 3
標識
生物 Rattus norvegicus
符號 CYP11B3
Entrez 353498
RefSeq (mRNA) NM_181824.1
RefSeq (蛋白質) NP_861545.1
UniProt P30100
其他數據
EC number 1.14.15.4
染色體 7: 116.16 - 116.26 Mb

參考文獻

  1. ^ Zhou MY, Gomez-Sanchez EP, Foecking MF, Gomez-Sanchez CE. Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC. Molecular and Cellular Endocrinology. October 1995, 114 (1–2): 137–45. PMID 8674838. doi:10.1016/0303-7207(95)03653-o.