葡萄糖-6-磷酸脫氫酶
蛋白質
葡萄糖-6-磷酸脫氫酶（英語：glucose-6-phosphate dehydrogenase，EC 1.1.1.49 （頁面存檔備份，存於互聯網檔案館））是一種以NAD+或NADP+為受體、作用於供體CH-OH基團上的氧化還原酶。這種酶能催化以下酶促反應：
| 葡萄糖-6-磷酸脫氫酶 | |||||||||
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| 葡萄糖-6-磷酸脫氫酶結構（PDB 1qki） | |||||||||
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| 識別碼 | |||||||||
| EC編號 | 1.1.1.49 | ||||||||
| CAS號 | 9001-40-5 | ||||||||
| 數據庫 | |||||||||
| IntEnz | IntEnz瀏覽 | ||||||||
| BRENDA | BRENDA入口 | ||||||||
| ExPASy | NiceZyme瀏覽 | ||||||||
| KEGG | KEGG入口 | ||||||||
| MetaCyc | 代謝路徑 | ||||||||
| PRIAM | 概述 | ||||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 基因本體 | AmiGO / EGO | ||||||||
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- D-葡萄糖-6-磷酸 + NADP+ D-葡萄糖酸-1,5-內酯-6-磷酸 + NADPH + H+
葡萄糖-6-磷酸脫氫酶主要參與磷酸戊糖途徑，也能緩慢地作用在β-D-葡萄糖等其他糖類上。這種酶可由其基質葡萄糖-6-磷酸活化。
葡萄糖-6-磷酸脫氫酶存在於眾多生物細胞內，高等植物擁有數種葡萄糖-6-磷酸脫氫酶的蛋白異構體（protein isoform），它們分佈於細胞質基質、和過氧化物酶體等細胞結構中[6]。如果人類表達葡萄糖-6-磷酸脫氫酶的基因有缺陷，將會導致葡萄糖-6-磷酸脫氫酶缺乏症，進而引發非免疫性溶血性貧血。
物種分佈
從細菌基因組到人類基因組中都有G6PD。一項對百餘個物種的G6PD多重序列比對研究顯示，不同物種間的G6PD基因相似度在30%到94%之間[7]，人與細菌間的相似度有30%[8]。
人類的G6PD基因存在兩種蛋白異構體[9]，此基因上至少有168種與疾病有關的突變[10]，通常為改變氨基酸的錯義突變[11]。
參考資料
- ^ 與葡萄糖-6-磷酸脱氢酶相關的疾病；在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000160211 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000089992 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Corpas FJ; et al. A dehydrogenase-mediated recycling system of NADPH in plant peroxisomes. Biochem. J. 1998, 330 (7): 777–784.
- ^ Kotaka M, Gover S, Vandeputte-Rutten L, Au SW, Lam VM, Adams MJ. Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase (PDF). Acta Crystallographica D. May 2005, 61 (Pt 5): 495–504. PMID 15858258. doi:10.1107/S0907444905002350
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- ^ Au SW, Gover S, Lam VM, Adams MJ. Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency. Structure. March 2000, 8 (3): 293–303. PMID 10745013. doi:10.1016/S0969-2126(00)00104-0 .
- ^ G6PD glucose-6-phosphate dehydrogenase [ Homo sapiens (human) ]. NCBI. [13 December 2015].
- ^ Šimčíková D, Heneberg P. Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases. Scientific Reports. December 2019, 9 (1): 18577. Bibcode:2019NatSR...918577S. PMC 6901466 . PMID 31819097. doi:10.1038/s41598-019-54976-4.
- ^ Kiani F, Schwarzl S, Fischer S, Efferth T. Three-dimensional modeling of glucose-6-phosphate dehydrogenase-deficient variants from German ancestry. PLOS ONE. July 2007, 2 (7): e625. Bibcode:2007PLoSO...2..625K. PMC 1913203 . PMID 17637841. doi:10.1371/journal.pone.0000625 .
延伸閱讀
- Vulliamy T, Beutler E, Luzzatto L. Variants of glucose-6-phosphate dehydrogenase are due to missense mutations spread throughout the coding region of the gene.. Hum. Mutat. 1993, 2 (3): 159–67. PMID 8364584. doi:10.1002/humu.1380020302.
- Mason PJ. New insights into G6PD deficiency.. Br. J. Haematol. 1996, 94 (4): 585–91. PMID 8826878.
- Wajcman H, Galactéros F. [Glucose 6-phosphate dehydrogenase deficiency: a protection against malaria and a risk for hemolytic accidents]. C. R. Biol. 2004, 327 (8): 711–20. PMID 15506519.