酮泛解酸

化合物

酮泛解酸(英語:Ketopantoic acid)是一種有機化合物結構簡式HOCH2(CH3)2CC(O)CO2H,結構上與泛解酸類似,屬於Ω-羥基酮酸,在體內由α-酮異戊酸羥甲基化英語Hydroxymethylation生成,在生理條件英語Physiological condition下以共軛鹼的形式存在[1][2]

酮泛解酸
別名 4-Hydroxy-3,3-dimethyl-2-oxobutanoic acid; 2-Dehydropantoic acid
識別
CAS號 470-30-4
PubChem 38
ChemSpider 37
SMILES
 
  • CC(C)(CO)C(=O)C(=O)O
Beilstein 2242422
ChEBI 17094
DrugBank DB03795
KEGG C00966
性質
化學式 C6H10O4
摩爾質量 146.14 g·mol−1
外觀 colorless or white
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

參考文獻

  1. ^ Matak-Vinković, Dijana; Vinković, Mladen; Saldanha, S. Adrian; Ashurst, Jennifer L.; von Delft, Frank; Inoue, Tsuyoshi; Miguel, Ricardo Nunez; Smith, Alison G.; Blundell, Tom L.; Abell, Chris. Crystal Structure of Escherichia coli Ketopantoate Reductase at 1.7 Å Resolution and Insight into the Enzyme Mechanism. Biochemistry. 2001, 40 (48): 14493–14500. PMID 11724562. doi:10.1021/bi011020w. 
  2. ^ Begley, Tadhg P.; Kinsland, Cynthia; Strauss, Erick. The Biosynthesis of Coenzyme a in Bacteria. Cofactor Biosynthesis. Vitamins & Hormones 61. 2001: 157–171. ISBN 9780127098616. PMID 11153265. doi:10.1016/S0083-6729(01)61005-7.