IDX-184

化合物

IDX-184是一種抗病毒藥物,開發用作NS5B英語NS5B RNA聚合酶抑制劑來治療丙型肝炎[1][2]儘管它在早期臨床試驗中顯示出一定效果,但並未通過IIb期試驗。[3]然而,該藥物的研究仍在繼續,並對一些新病毒(如寨卡病毒[4][5]MERS[6]SARS-CoV-2冠狀病毒[7][8])顯示出一定的藥物活性。

IDX-184
法律規範狀態
法律規範
  • 研究藥物
識別資訊
  • S-[2-{[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-(benzylamino)phosphoryl}oxyethyl] 3-hydroxy-2,2-dimethylpropanethioate
CAS號1036915-08-8  checkY
PubChem CID
ChemSpider
UNII
化學資訊
化學式C25H35N6O9PS
摩爾質量626.6
3D模型(JSmol英語JSmol
  • C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(NCC4=CC=CC=C4)OCCSC(=O)C(C)(C)CO)O)O
  • InChI=1S/C25H35N6O9PS/c1-24(2,13-32)22(35)42-10-9-38-41(37,28-11-15-7-5-4-6-8-15)39-12-16-18(33)25(3,36)21(40-16)31-14-27-17-19(31)29-23(26)30-20(17)34/h4-8,14,16,18,21,32-33,36H,9-13H2,1-3H3,(H,28,37)(H3,26,29,30,34)/t16-,18-,21-,25-,41?/m1/s1
  • Key:FGHMGRXAHIXTBM-TWFJNEQDSA-N

參考文獻

  1. ^ Elfiky AA, Elshemey WM. IDX-184 is a superior HCV direct-acting antiviral drug: a QSAR study. Med Chem Res. 2016;25(5):1005-1008. doi:10.1007/s00044-016-1533-y PMID 32214769
  2. ^ Elfiky AA. Novel Guanosine Derivatives as Anti-HCV NS5b Polymerase: A QSAR and Molecular Docking Study. Med Chem. 2019;15(2):130-137. doi:10.2174/1573406414666181015152511 PMID 30324891
  3. ^ Gentile I, Buonomo AR, Zappulo E, Borgia G. Discontinued drugs in 2012 - 2013: hepatitis C virus infection. Expert Opin Investig Drugs. 2015 Feb;24(2):239-51. doi:10.1517/13543784.2015.982274 PMID 25384989
  4. ^ Elfiky AA. Zika viral polymerase inhibition using anti-HCV drugs both in market and under clinical trials. J Med Virol. 2016 Dec;88(12):2044-2051. doi:10.1002/jmv.24678 PMID 27604059
  5. ^ Elfiky AA, Ismail AM. Molecular docking revealed the binding of nucleotide/side inhibitors to Zika viral polymerase solved structures. SAR QSAR Environ Res. 2018 May;29(5):409-418. doi:10.1080/1062936X.2018.1454981 PMID 29652194
  6. ^ Elfiky AA, Mahdy SM, Elshemey WM. Quantitative structure-activity relationship and molecular docking revealed a potency of anti-hepatitis C virus drugs against human corona viruses. J Med Virol. 2017 Jun;89(6):1040-1047. doi:10.1002/jmv.24736 PMID 27864902
  7. ^ Elfiky AA. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci. 2020 May 1;248:117477. doi:10.1016/j.lfs.2020.117477 PMID 32119961
  8. ^ Elfiky AA. Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sci. 2020 Mar 25:117592. doi:10.1016/j.lfs.2020.117592 PMID 32222463