H1299细胞
H1299 (也称为NCI-H1299[1]、CRL-5803) 是源自淋巴结的人类非小细胞肺癌细胞系，在研究中得到广泛应用[2]。H1299细胞与其他永生细胞系一样可以无限期分裂，并且因p53基因的纯合子部分缺失，故而不表达肿瘤抑制基因p53蛋白，说明了它们的增殖倾向[3]。有研究指出这些细胞会分泌神经调节素B，但是不会分泌GRP[2]。
参考资料
- ^ NCI-Navy Medical Oncology Branch cell line supplement.. Journal of cellular biochemistry. Supplement. 1996, 24: 1–291 [2019-11-29]. PMID 8965489.
- ^ 2.0 2.1 Giaccone, G; Battey, J; Gazdar, AF; Oie, H; Draoui, M; Moody, TW. Neuromedin B is present in lung cancer cell lines.. Cancer research. 1992-05-01, 52 (9 Suppl): 2732s–2736s [2019-11-29]. PMID 1563005.
- ^ Lin, DL; Chang, C. p53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor superfamily.. The Journal of biological chemistry. 1996-06-21, 271 (25): 14649–52 [2019-11-29]. PMID 8663350. doi:10.1074/jbc.271.25.14649.