甘油-3-磷酸脱氢酶 (NAD+)

甘油-3-磷酸脱氢酶 (NAD⁺)（英语：glycerol-3-phosphate dehydrogenase (NAD⁺)，EC 1.1.1.8 （页面存档备份，存于互联网档案馆））是一种以NAD⁺或NADP⁺为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：

甘油-3-磷酸脱氢酶 (NAD+)
人源甘油-3-磷酸脱氢酶1（PDB 1x0v）
命名 系统命名 sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase 缩写 GPD 别名 α-glycerol phosphate dehydrogenase (NAD); α-glycerophosphate dehydrogenase (NAD); glycerol 1-phosphate dehydrogenase; glycerol phosphate dehydrogenase (NAD); glycerophosphate dehydrogenase (NAD); hydroglycerophosphate dehydrogenase; L-α-glycerol phosphate dehydrogenase; L-α-glycerophosphate dehydrogenase; L-glycerol phosphate dehydrogenase; L-glycerophosphate dehydrogenase; NAD-α-glycerophosphate dehydrogenase; NAD-dependent glycerol phosphate dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase; NAD-L-glycerol-3-phosphate dehydrogenase; NAD-linked glycerol 3-phosphate dehydrogenase; NADH-dihydroxyacetone phosphate reductase; glycerol-3-phosphate dehydrogenase (NAD)
识别码
EC编号	1.1.1.8
CAS号	9075-65-4
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本体	AmiGO / EGO
搜索 PMC 相关文献 PubMed 相关文献

sn-甘油-3-磷酸 + NAD⁺ $\rightleftharpoons$ 磷酸甘油酮 + NADH + H⁺

甘油-3-磷酸脱氢酶 (NAD⁺)主要参与甘油磷酸脂的代谢过程。

参考文献

• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.). The Enzymes 7 2nd. New York: Academic Press. 1963: 85–96. 

• Brosemer RW, Kuhn RW. Comparative structural properties of honeybee and rabbit alpha-glycerophosphate dehydrogenases. Biochemistry. 1969, 8 (5): 2095–105. PMID 4307630. doi:10.1021/bi00833a047. 

• O'Brien SJ, MacIntyre RJ. The -glycerophosphate cycle in Drosophila melanogaster. I Biochemical and developmental aspects. Biochem. Genet. 1972, 7 (2): 141–61. PMID 4340553. doi:10.1007/BF00486085. 

• Warkentin DL, Fondy TP. Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme. Eur. J. Biochem. 1973, 36 (1): 97–109. PMID 4200180. doi:10.1111/j.1432-1033.1973.tb02889.x. 

• Albertyn J, van Tonder A, Prior BA. Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae. FEBS. Lett. 1992, 308 (2): 130–2. PMID 1499720. doi:10.1016/0014-5793(92)81259-O. 

• Koekemoer TC, Litthauer D, Oelofsen W. Isolation and characterization of adipose tissue glycerol-3-phosphate dehydrogenase. Int. J. Biochem. Cell. Biol. 1995, 27 (6): 625–32. PMID 7671141. doi:10.1016/1357-2725(95)00012-E.