C1498

C1498是可作为急性骨髓性白血病模型的小鼠白血病细胞系^[1]，具有很少的细胞表面造血标记物^[2]，并且是通过分泌可溶性细胞因子抑制着正常小鼠造血的功能^[3]。C1498细胞在培养基中表达低水平的细胞程式死亡-配体1 (PD-L1) ^[4]，然而在生物体内则显著上调PD-L1的表达^[5]。

历史

1941年，科学家从10个月大且患有白血病的雌性 C57BL/6小鼠中分离出C1498细胞，并且将其以静脉注射的方式注射到同系小鼠的体内，导致其患有急性白血病。C1498细胞自始成为急性白血病的模型，有多份文献记载着通过静脉、皮下或腹膜的途径，将高度增殖的C1498细胞，注射入易受感染的小鼠后，血液、脾脏和淋巴结等造血器官，以及卵巢和肾脏等非造血器官的情况^[6]^[7]。较早前的研究认为小鼠模型诱导粒细胞性单核细胞性白血病^[6]^[8]或骨髓单核细胞性白血病^[2]。

在2002年，有研究将这种癌症正式描述为鼠类NKT细胞白血病^[1]，惟因许多研究都是在1950年代-1970年代进行而缺乏有关细胞及白血病疾病的详细及更新的公开资料，关于C1498细胞的性质及其在小鼠中诱发的相关白血病，在不同文献具有差异性^[9]。

在2016年，有研究指出注射C1498细胞至小鼠体内后，观察到的许多白血病特征与人类急性髓单核细胞白血病相同^[10]，入侵的白血病细胞导致成熟的和未成熟的祖细胞及前体骨髓造血细胞减，并且发现C1498细胞以较高的比率存在于外周血^[9]。

参考资料

^ ^1.0 ^1.1 LaBelle, JL; Truitt, RL. Characterization of a murine NKT cell tumor previously described as an acute myelogenous leukemia.. Leukemia & lymphoma. 2002-08, 43 (8): 1637–44 [2019-12-14]. PMID 12400607. doi:10.1080/1042819021000002974.
^ ^2.0 ^2.1 Boyer, MW; Orchard, PJ; Gorden, KB; Anderson, PM; Mclvor, RS; Blazar, BR. Dependency on intercellular adhesion molecule recognition and local interleukin-2 provision in generation of an in vivo CD8+ T-cell immune response to murine myeloid leukemia.. Blood. 1995-05-01, 85 (9): 2498–506 [2019-12-14]. PMID 7727779.
^ Quesenberry, PJ; Rappeport, JM; Fountebouni, A; Sullivan, R; Zuckerman, K; Ryan, M. Inhibition of normal murine hematopoiesis by leukemic cells.. The New England journal of medicine. 1978-07-13, 299 (2): 71–5 [2019-12-14]. PMID 351395. doi:10.1056/NEJM197807132990204.
^ Zhang, L; Gajewski, TF; Kline, J. PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model.. Blood. 2009-08-20, 114 (8): 1545–52 [2019-12-14]. PMID 19417208. doi:10.1182/blood-2009-03-206672.
^ DAVERN; BASUS; GARCIAMANEROG等. Abstract 3205: Defining the immune checkpoint landscape of acute myeloid leukemia (AML). Blood. 2016, 128 (22): 2900–05. doi:10.1158/1538-7445.AM2016-3205.
^ ^6.0 ^6.1 GOLDIE, H; BUTLER, CH; ANDERSON, MM; MAXWELL, MC; HAHN, PF. Growth characteristics of free C1498 granulocytic leukemia tumor cells in the peritoneal fluid and the blood of C57 mice.. Cancer research. 1953-02, 13 (2): 125–9 [2019-12-14]. PMID 13042796.
^ TANAKA, KK; ROBERTS, E. BIOLOGICAL STUDIES OF E.L.4 LYMPHOMA AND C-1498 LEUKEMIA IN SUSCEPTIBLE (C57BL) AND RESISTANT (B10.D2) MICE.. Cancer research. 1964-11, 24: 1785–97 [2019-12-14]. PMID 14230926.
^ Graham JD; McMahon Welch C; Patchen ML. Studies of an implanted murine myelogenous leukemia C1498. The Ohio Journal of Science. 1975, 75 (4): 202–208 [2019-12-14].
^ ^9.0 ^9.1 Mopin, A; Driss, V; Brinster, C. A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model.. Journal of visualized experiments : JoVE. 2016-10-14, (116) [2019-12-14]. PMID 27768040. doi:10.3791/54270.
^ Xu, Y; McKenna, RW; Wilson, KS; Karandikar, NJ; Schultz, RA; Kroft, SH. Immunophenotypic identification of acute myeloid leukemia with monocytic differentiation.. Leukemia. 2006-07, 20 (7): 1321–4 [2019-12-14]. PMID 16642046. doi:10.1038/sj.leu.2404242.

外部链接

Cellosaurus entry for C1498（页面存档备份，存于互联网档案馆）

[b-1] 1.0 ^1.1 LaBelle, JL; Truitt, RL. Characterization of a murine NKT cell tumor previously described as an acute myelogenous leukemia.. Leukemia & lymphoma. 2002-08, 43 (8): 1637–44 [2019-12-14]. PMID 12400607. doi:10.1080/1042819021000002974.

[d-2] 2.0 ^2.1 Boyer, MW; Orchard, PJ; Gorden, KB; Anderson, PM; Mclvor, RS; Blazar, BR. Dependency on intercellular adhesion molecule recognition and local interleukin-2 provision in generation of an in vivo CD8+ T-cell immune response to murine myeloid leukemia.. Blood. 1995-05-01, 85 (9): 2498–506 [2019-12-14]. PMID 7727779.

[3] Quesenberry, PJ; Rappeport, JM; Fountebouni, A; Sullivan, R; Zuckerman, K; Ryan, M. Inhibition of normal murine hematopoiesis by leukemic cells.. The New England journal of medicine. 1978-07-13, 299 (2): 71–5 [2019-12-14]. PMID 351395. doi:10.1056/NEJM197807132990204.

[4] Zhang, L; Gajewski, TF; Kline, J. PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model.. Blood. 2009-08-20, 114 (8): 1545–52 [2019-12-14]. PMID 19417208. doi:10.1182/blood-2009-03-206672.

[5] DAVERN; BASUS; GARCIAMANEROG等. Abstract 3205: Defining the immune checkpoint landscape of acute myeloid leukemia (AML). Blood. 2016, 128 (22): 2900–05. doi:10.1158/1538-7445.AM2016-3205.

[a-6] 6.0 ^6.1 GOLDIE, H; BUTLER, CH; ANDERSON, MM; MAXWELL, MC; HAHN, PF. Growth characteristics of free C1498 granulocytic leukemia tumor cells in the peritoneal fluid and the blood of C57 mice.. Cancer research. 1953-02, 13 (2): 125–9 [2019-12-14]. PMID 13042796.

[7] TANAKA, KK; ROBERTS, E. BIOLOGICAL STUDIES OF E.L.4 LYMPHOMA AND C-1498 LEUKEMIA IN SUSCEPTIBLE (C57BL) AND RESISTANT (B10.D2) MICE.. Cancer research. 1964-11, 24: 1785–97 [2019-12-14]. PMID 14230926.

[8] Graham JD; McMahon Welch C; Patchen ML. Studies of an implanted murine myelogenous leukemia C1498. The Ohio Journal of Science. 1975, 75 (4): 202–208 [2019-12-14].

[c-9] 9.0 ^9.1 Mopin, A; Driss, V; Brinster, C. A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model.. Journal of visualized experiments : JoVE. 2016-10-14, (116) [2019-12-14]. PMID 27768040. doi:10.3791/54270.

[10] Xu, Y; McKenna, RW; Wilson, KS; Karandikar, NJ; Schultz, RA; Kroft, SH. Immunophenotypic identification of acute myeloid leukemia with monocytic differentiation.. Leukemia. 2006-07, 20 (7): 1321–4 [2019-12-14]. PMID 16642046. doi:10.1038/sj.leu.2404242.

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