SK-OV-3是一种二倍体卵巢癌细胞系,最初在1973年分离自一名64岁白人女性囊腺癌患者的腹水[1]。在63.3%的SK-OV-3细胞中,染色体的模态数为43,而范围则为42至45。 SK-OV-3对许多用于鉴定上皮来源癌的抗原,呈阳性反应,包括波形蛋白、高分子量细胞角蛋白英语Cytokeratin、低分子量细胞角蛋白、上皮膜抗原(epithelial membrane antigen)和蛋白酪氨酸磷酸酶C型受体[2]。早期的研究报告指出,SK-OV-3细胞不会表达CA-125(一种细胞表面抗原),而该抗原后来成为检测卵巢癌最常用的生物标志物,并且通过剂量反应曲线英语Dose–response relationship表明SK-OV-3细胞对敏感[3][4]。随后的研究更显示,SK-OV-3细胞中CA-125 C末端结构域的异位表达,降低了其对顺铂诱导的细胞凋亡的敏感性[5]。目前已经有研究指出其具有中度分化能力,将SK-OV-3注入裸鼠后,裸鼠体内会产生大的实体肿瘤,并且会松散地附着在骨盆区域、肠或大网膜英语Greater omentum脂肪[2]

参考资料

  1. ^ Fogh, J; Fogh, JM; Orfeo, T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.. Journal of the National Cancer Institute. 1977-07, 59 (1): 221–6 [2020-01-17]. PMID 327080. doi:10.1093/jnci/59.1.221. (原始内容存档于2020-01-12). 
  2. ^ 2.0 2.1 Shaw, TJ; Senterman, MK; Dawson, K; Crane, CA; Vanderhyden, BC. Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer.. Molecular therapy : the journal of the American Society of Gene Therapy. 2004-12, 10 (6): 1032–42 [2020-01-17]. PMID 15564135. doi:10.1016/j.ymthe.2004.08.013. [永久失效链接]
  3. ^ Fogh, J. Human tumor lines for cancer research.. Cancer investigation. 1986, 4 (2): 157–84 [2020-01-17]. PMID 3518877. doi:10.3109/07357908609038260. [永久失效链接]
  4. ^ Suh, KS; Park, SW; Castro, A; Patel, H; Blake, P; Liang, M; Goy, A. Ovarian cancer biomarkers for molecular biosensors and translational medicine.. Expert review of molecular diagnostics. 2010-11, 10 (8): 1069–83 [2020-01-17]. PMID 21080822. doi:10.1586/erm.10.87. [永久失效链接]
  5. ^ Boivin, M; Lane, D; Piché, A; Rancourt, C. CA125 (MUC16) tumor antigen selectively modulates the sensitivity of ovarian cancer cells to genotoxic drug-induced apoptosis.. Gynecologic oncology. 2009-12, 115 (3): 407–13 [2020-01-17]. PMID 19747716. doi:10.1016/j.ygyno.2009.08.007. [永久失效链接]

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