含EGF模塊黏液素樣激素受體或全稱含表皮生長因子模塊黏液素樣激素受體（英語：Epidermal growth factor module-containing Mucin-like hormone Receptor），縮寫為EMR，是G蛋白偶聯受體密切相關的亞組。這些受體具有獨特的混合結構，其中細胞外表皮生長因子（EGF）樣結構域通過黏液素（又叫黏蛋白）樣莖與G蛋白偶聯受體結構域融合。[1][2][3][4]EMR有四種標記為1-4的變體，每種變體均由單獨的基因編碼。這些受體主要在免疫系統細胞中表達並結合CD55等配體。[5]
參考資料
- ^ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M. EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. Genomics. 1995, 26 (2): 334–44. PMID 7601460. doi:10.1016/0888-7543(95)80218-B.
- ^ Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. Genomics. 2000, 67 (2): 188–200. PMID 10903844. doi:10.1006/geno.2000.6238.
- ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. J. Biol. Chem. 2001, 276 (22): 18863–70. PMID 11279179. doi:10.1074/jbc.M101147200.
- ^ Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. DNA Seq. 2006, 17 (1): 8–14. PMID 16753812. S2CID 11216477. doi:10.1080/10425170500355737.
- ^ Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J. The EGF-TM7 family: a postgenomic view. Immunogenetics. 2004, 55 (10): 655–66. PMID 14647991. S2CID 28689160. doi:10.1007/s00251-003-0625-2.
外部連結
