羥甲基戊二酸單醯輔酶A還原酶 (NADPH)

此條目介紹的是NADP⁺為受體的酶。關於同名但以NAD⁺為受體的酶，請見「羥甲基戊二酸單醯輔酶A還原酶」。

羥甲基戊二酸單醯輔酶A還原酶 (NADPH)（英語：hydroxymethylglutaryl-CoA reductase (NADPH)，EC 1.1.1.34 （頁面存檔備份，存於網際網路檔案館））是一種以NAD⁺或NADP⁺為受體、作用於供體CH-OH基團上的氧化還原酶。這種酶能催化以下酶促反應：

羥甲基戊二酸單醯輔酶A還原酶 (NADPH)
羥甲基戊二酸單醯輔酶A還原酶晶體結構（PDB 1dq8）
命名 系統命名 (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating) 縮寫 別名 hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate); 3-hydroxy-3-methylglutaryl-CoA reductase; β-hydroxy-β-methylglutaryl coenzyme A reductase; hydroxymethylglutaryl CoA reductase (NADPH); S-3-hydroxy-3-methylglutaryl-CoA reductase; NADPH-hydroxymethylglutaryl-CoA reductase; HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA); 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase (NADPH2)
識別碼
EC編號	1.1.1.34
CAS號	9028-35-7
資料庫
IntEnz	IntEnz瀏覽
BRENDA	BRENDA入口
ExPASy	NiceZyme瀏覽
KEGG	KEGG入口
MetaCyc	代謝路徑
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本體	AmiGO / EGO
搜索 PMC 相關文獻 PubMed 相關文獻

(R)-甲羥戊酸 + CoA + 2 NADP⁺ $\rightleftharpoons$ (S)-3-羥基-3-甲基戊二醯輔酶A + 2 NADPH + 2 H⁺

羥甲基戊二酸單醯輔酶A還原酶 (NADPH)主要參與諸如膽固醇等類固醇的合成。用於降低膽固醇的他汀類藥物通過抑制這種酶來發揮作用。

參考文獻

• Bucher NLR, Overath P and Lynen F. beta-Hydroxy-beta-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver. Biochim. Biophys. Acta. 1960, 40: 491–501. PMID 13805544. doi:10.1016/0006-3002(60)91390-1. 
• DURR IF, RUDNEY H. The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid. J. Biol. Chem. 1960, 235: 2572–8. PMID 13818862. 
• Kawachi T, Rudney H. Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver. Biochemistry. 1970, 9 (8): 1700–5. PMID 4985697. doi:10.1021/bi00810a008.