8-苯基茶鹼
化合物
8-苯基茶鹼(英語:8-Phenyltheophylline,縮寫8-PT,或稱為8-苯基-1,3-二甲基黃嘌呤,8-phenyl-1,3-dimethylxanthine),分子式C13H12N4O2,是一種黃嘌呤衍生物,可作為腺苷受體A1和A2A的選擇性拮抗劑,但不具備磷酸二酯酶抑制藥活性。[1][2][3]
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CAS號 | 961-45-5 |
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化學資訊 | |
化學式 | C13H12N4O2 |
摩爾質量 | 256.27 g·mol−1 |
3D模型(JSmol) | |
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參考文獻
- ^ Scotini E, Carpenedo F, Fassina G. New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities. Pharmacological Research Communications. February 1983, 15 (2): 131–43. PMID 6844374. doi:10.1016/s0031-6989(83)80055-1.
- ^ Rabe KF, Magnussen H, Dent G. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. The European Respiratory Journal. April 1995, 8 (4): 637–42. PMID 7664866. doi:10.1183/09031936.95.08040637.
- ^ Howell LL, Morse WH, Spealman RD. Respiratory effects of xanthines and adenosine analogs in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. September 1990, 254 (3): 786–91. PMID 2395111.