优降宁

优降宁
臨床資料
MedlinePlus	a682088
ATC碼	C02KC01 (WHO) C02LL01;
识别信息
	IUPAC命名法 N-benzyl-N-methylprop-2-yn-1-amine; ;
CAS号	555-57-7
PubChem CID	4688;
IUPHAR/BPS	7262;
DrugBank	DB01626 ;
ChemSpider	4526 ;
UNII	9MV14S8G3E;
ChEMBL	ChEMBL673 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID3023423 ;
ECHA InfoCard	100.008.275
化学信息
化学式	C11H13N
摩尔质量	159.23 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C#CCN(C)Cc1ccccc1;
	InChI InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3 ; Key:DPWPWRLQFGFJFI-UHFFFAOYSA-N ;

优降宁是不可逆、选择性的单胺氧化酶抑制剂（MAO-A（英语：Monoamine oxidase A）和MAO-B（英语：Monoamine oxidase B）的IC₅₀分别为11.52 nM和8.20 nM）。^[1]^[2]1963年，它由雅培以抗高血压药的形式进入美国及英国市场，商品名Eutonyl。同样于1960年代进入市场的单胺氧化酶抑制剂还有尼亚拉胺（英语：nialamide）、异卡波肼、苯乙肼（英语：phenelzine）、反苯环丙胺。^[3]^:146^[4]^:60^[5]^[6]优降宁于2007年被停用。^[7]它除了作为单胺氧化酶抑制剂，也会与单胺氧化酶的别构中心I₂咪唑啉受体（英语：Imidazoline receptor）结合。^[8]

参见

参考资料

^ Fisar Z, Hroudová J, Raboch J. Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.. Neuro Endocrinol Lett. 2010, 31 (5): 645–56. PMID 21200377.
^ Murphy DL, Karoum F, Pickar D, et al. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (Clorgyline) or MAO-B (Selegiline and pargyline). MAO — the Mother of all Amine Oxidases. Journal of Neural Transmission. Supplement 52. 1998: 39–48. ISBN 978-3-211-83037-6. PMID 9564606. doi:10.1007/978-3-7091-6499-0_5. |journal=被忽略 (帮助)
^ Edward Shorter, A historical dictionary of psychiatry. Oxford University Press, Inc 2005. ISBN 0195176685
^ William M. Wardell and Louis Lasagna. Regulation Drug Development (Evaluative Studies 21) American Enterprise Institute (1975) ISBN 0844731676
^ Council on Drugs New Drugs and Developments in Therapeutics: Pargyline Hydrochloride (Eutonyl) （页面存档备份，存于互联网档案馆） JAMA. 1963;184(11):887. doi:10.1001/jama.1963.03700240079013.
^ Eutonyl and MAO inhibitors. Drug and Therapeutics Bulletin. 15 November 1963, 1 (15): 59–60 [2024-02-18]. ISSN 1755-5248. S2CID 220162992. doi:10.1136/dtb.1.15.59. （原始内容存档于2024-06-06）（英语）. Pargyline is promoted only for the treatment of hypertension, and not for depression.
^ W. Steven Pray. Interactions Between Nonprescription Products and Psychotropic Medications. www.medscape.com. 2007 [2024-02-18]. （原始内容存档于2021-05-15）.
^ Critical Reviews in Neurobiology. CRC Press. 1995: 43.

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[pmid21200377-1] Fisar Z, Hroudová J, Raboch J. Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.. Neuro Endocrinol Lett. 2010, 31 (5): 645–56. PMID 21200377.

[pmid9564606-2] Murphy DL, Karoum F, Pickar D, et al. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (Clorgyline) or MAO-B (Selegiline and pargyline). MAO — the Mother of all Amine Oxidases. Journal of Neural Transmission. Supplement 52. 1998: 39–48. ISBN 978-3-211-83037-6. PMID 9564606. doi:10.1007/978-3-7091-6499-0_5. |journal=被忽略 (帮助)

[3] Edward Shorter, A historical dictionary of psychiatry. Oxford University Press, Inc 2005. ISBN 0195176685

[4] William M. Wardell and Louis Lasagna. Regulation Drug Development (Evaluative Studies 21) American Enterprise Institute (1975) ISBN 0844731676

[5] Council on Drugs New Drugs and Developments in Therapeutics: Pargyline Hydrochloride (Eutonyl) （页面存档备份，存于互联网档案馆） JAMA. 1963;184(11):887. doi:10.1001/jama.1963.03700240079013.

[6] Eutonyl and MAO inhibitors. Drug and Therapeutics Bulletin. 15 November 1963, 1 (15): 59–60 [2024-02-18]. ISSN 1755-5248. S2CID 220162992. doi:10.1136/dtb.1.15.59. （原始内容存档于2024-06-06）（英语）. Pargyline is promoted only for the treatment of hypertension, and not for depression.

[7] W. Steven Pray. Interactions Between Nonprescription Products and Psychotropic Medications. www.medscape.com. 2007 [2024-02-18]. （原始内容存档于2021-05-15）.

[8] Critical Reviews in Neurobiology. CRC Press. 1995: 43.

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