培妥莫单抗

培妥莫单抗
单克隆抗体
种类	?
目標	MUC1
臨床資料
商品名（英语：Drug nomenclature）	Theragyn
给药途径	腹膜给药
ATC碼	未分配;
识别信息
CAS号	646032-04-4
ChemSpider	none;

培妥莫单抗（INN：pemtumomab；商品名：Theragyn），或译潘妥莫单抗，是一种用于治疗癌症的小鼠单克隆抗体。该药物通过多态性上皮黏蛋白（PEM或MUC1）对多种类型的癌症（例如卵巢癌和腹膜癌）具有亲和力，并将放射性同位素钇-90输送到肿瘤中。^[1]截至2009年，它正在进行III期临床试验。^[2]

它已在欧洲获得孤儿药地位。^[3]

参考资料

^ Oei AL, Moreno M, Verheijen RH, Sweep FC, Thomas CM, Massuger LF, von Mensdorff-Pouilly S. Induction of IgG antibodies to MUC1 and survival in patients with epithelial ovarian cancer. International Journal of Cancer. October 2008, 123 (8): 1848–53. PMID 18661524. S2CID 2287723. doi:10.1002/ijc.23725  .
^ Clinical trial number NCT00004115 for "Monoclonal Antibody Therapy in Treating Patients With Ovarian Cancer or Primary Peritoneal Cancer in Remission Following Surgery and Chemotherapy" at ClinicalTrials.gov
^ Antisoma's Lead Product, Pemtumomab Granted European Orphan Drug Status^{[失效連結]}

[1] Oei AL, Moreno M, Verheijen RH, Sweep FC, Thomas CM, Massuger LF, von Mensdorff-Pouilly S. Induction of IgG antibodies to MUC1 and survival in patients with epithelial ovarian cancer. International Journal of Cancer. October 2008, 123 (8): 1848–53. PMID 18661524. S2CID 2287723. doi:10.1002/ijc.23725  .

[2] Clinical trial number NCT00004115 for "Monoclonal Antibody Therapy in Treating Patients With Ovarian Cancer or Primary Peritoneal Cancer in Remission Following Surgery and Chemotherapy" at ClinicalTrials.gov

[3] Antisoma's Lead Product, Pemtumomab Granted European Orphan Drug Status^{[失效連結]}

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