8-环戊基-1,3-二甲基黄嘌呤

化合物

8-环戊基-1,3-二甲基黄嘌呤,别名8-环戊基茶碱,简称8-CPTCPX,是一种药物,可作为腺苷受体的有效选择性拮抗剂,对A1受体亚型具有一定的选择性,同时也对非选择性磷酸二酯酶抑制剂。它对动物有兴奋作用,效力略高于咖啡因[1][2]

8-环戊基-1,3-二甲基黄嘌呤
Skeletal formula of 8-CPT
Ball-and-stick model of the 8-CPT molecule
临床资料
ATC码
  • 未分配
法律规范状态
法律规范
  • 不受管制
识别信息
  • 8-Cyclopentyl-1,3-dimethyl-7H-purine-2,6-dione
CAS号35873-49-5  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C12H16N4O2
摩尔质量248.29 g·mol−1
3D模型(JSmol英语JSmol
  • Cn3c(=O)c2nc(C1CCCC1)[nH]c2n(C)c3=O
  • InChI=1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14) checkY
  • Key:SCVHFRLUNIOSGI-UHFFFAOYSA-N checkY

参见

参考资料

  1. ^ Spealman RD. Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism. Psychopharmacology. 1988, 95 (1): 19–24. PMID 3133696. S2CID 11539292. doi:10.1007/bf00212759. 
  2. ^ Karcz-Kubicha M, Antoniou K, Terasmaa A, Quarta D, Solinas M, Justinova Z, et al. Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration. Neuropsychopharmacology. July 2003, 28 (7): 1281–91. PMID 12700682. doi:10.1038/sj.npp.1300167 .