8-環戊基-1,3-二甲基黃嘌呤

化合物

8-環戊基-1,3-二甲基黃嘌呤,別名8-環戊基茶鹼,簡稱8-CPTCPX,是一種藥物,可作為腺苷受體的有效選擇性拮抗劑,對A1受體亞型具有一定的選擇性,同時也對非選擇性磷酸二酯酶抑制劑。它對動物有興奮作用,效力略高於咖啡因[1][2]

8-環戊基-1,3-二甲基黃嘌呤
Skeletal formula of 8-CPT
Ball-and-stick model of the 8-CPT molecule
臨床資料
ATC碼
  • 未分配
法律規範狀態
法律規範
  • 不受管制
識別資訊
  • 8-Cyclopentyl-1,3-dimethyl-7H-purine-2,6-dione
CAS號35873-49-5  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C12H16N4O2
摩爾質量248.29 g·mol−1
3D模型(JSmol英語JSmol
  • Cn3c(=O)c2nc(C1CCCC1)[nH]c2n(C)c3=O
  • InChI=1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14) checkY
  • Key:SCVHFRLUNIOSGI-UHFFFAOYSA-N checkY

參見

參考資料

  1. ^ Spealman RD. Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism. Psychopharmacology. 1988, 95 (1): 19–24. PMID 3133696. S2CID 11539292. doi:10.1007/bf00212759. 
  2. ^ Karcz-Kubicha M, Antoniou K, Terasmaa A, Quarta D, Solinas M, Justinova Z, et al. Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration. Neuropsychopharmacology. July 2003, 28 (7): 1281–91. PMID 12700682. doi:10.1038/sj.npp.1300167 .