選擇素(英語:selectins,又譯為選擇蛋白,或稱為表面抗原分化簇-62,即CD62)是一個細胞粘附分子CAM家族,包括有E-選擇素、L 選擇素、P選擇素等。所有的選擇素都是單鏈跨膜糖蛋白,與C-型凝集素屬性類似,有着相似的N-末端和鈣依賴性[2]。選擇素能與糖鏈基團結合而被視為一種凝集素[3]

P-選擇素與糖類(圖上方)結合[1]

結構

另見

參考文獻

  1. ^ PDB 1G1R; Somers WS, Tang J, Shaw GD, Camphausen RT. Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell. October 2000, 103 (3): 467–79. PMID 11081633. doi:10.1016/S0092-8674(00)00138-0. 
  2. ^ Cotran; Kumar, Collins. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. 1998. ISBN 0-7216-7335-X. 
  3. ^ Parham, Peter. The immune system 2nd. New York: Garland Science. 2005: 244–245. ISBN 0-8153-4093-1. 

外部連結