选择素(英语:selectins,又译为选择蛋白,或称为表面抗原分化簇-62,即CD62)是一个细胞粘附分子CAM家族,包括有E-选择素、L 选择素、P选择素等。所有的选择素都是单链跨膜糖蛋白,与C-型凝集素属性类似,有着相似的N-末端和钙依赖性[2]。选择素能与糖链基团结合而被视为一种凝集素[3]

P-选择素与糖类(图上方)结合[1]

结构

另见

参考文献

  1. ^ PDB 1G1R; Somers WS, Tang J, Shaw GD, Camphausen RT. Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell. October 2000, 103 (3): 467–79. PMID 11081633. doi:10.1016/S0092-8674(00)00138-0. 
  2. ^ Cotran; Kumar, Collins. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. 1998. ISBN 0-7216-7335-X. 
  3. ^ Parham, Peter. The immune system 2nd. New York: Garland Science. 2005: 244–245. ISBN 0-8153-4093-1. 

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